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Literature DB >> 31683182

Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.

Abstract

Recently there has been a flurry of interest in the regulation of the homo-dimeric calcium-activated chloride channel ANO1 (also known as TMEM16A) by phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2). These recent studies show that upon Ca2+ binding, PI(4,5)P2 cooperates to maintain the conductive state of ANO1. PI(4,5)P2 does so by binding to sites or modules on the protein's cytosolic side. These findings add a new function to the PI(4,5)P2 repertoire and a new dimension to ANO1 gating.

Entities: CellLine Chemical Disease Gene Species

Keywords: Anion channels; Calcium; Ion channel gating; Ion channel regulation; Phospholipids

Mesh：

Substances：

Year: 2019 PMID： 31683182 PMCID： PMC6913893 DOI： 10.1016/j.ceca.2019.102103

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

29 in total

Review 1. TMEM16 proteins: unknown structure and confusing functions.

Authors: Alessandra Picollo; Mattia Malvezzi; Alessio Accardi
Journal: J Mol Biol Date: 2014-10-17 Impact factor: 5.469

2. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.

Authors: Qinghuan Xiao; Kuai Yu; Patricia Perez-Cornejo; Yuanyuan Cui; Jorge Arreola; H Criss Hartzell
Journal: Proc Natl Acad Sci U S A Date: 2011-05-09 Impact factor: 11.205

Review 3. Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.

Authors: Diomedes E Logothetis; Vasileios I Petrou; Miao Zhang; Rahul Mahajan; Xuan-Yu Meng; Scott K Adney; Meng Cui; Lia Baki
Journal: Annu Rev Physiol Date: 2014-10-02 Impact factor: 19.318

4. Calcium-dependent phospholipid scrambling by TMEM16F.

Authors: Jun Suzuki; Masato Umeda; Peter J Sims; Shigekazu Nagata
Journal: Nature Date: 2010-11-24 Impact factor: 49.962

Review 5. Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.

Authors: Karl Kunzelmann; Ines Cabrita; Podchanart Wanitchakool; Jiraporn Ousingsawat; Lalida Sirianant; Roberta Benedetto; Rainer Schreiber
Journal: Pflugers Arch Date: 2015-12-23 Impact factor: 3.657

6. Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.

Authors: H A T Pritchard; N Leblanc; A P Albert; I A Greenwood
Journal: Br J Pharmacol Date: 2014-09 Impact factor: 8.739

7. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

Authors: Christian J Peters; John M Gilchrist; Jason Tien; Neville P Bethel; Lijun Qi; Tingxu Chen; Lynn Wang; Yuh Nung Jan; Michael Grabe; Lily Y Jan
Journal: Neuron Date: 2018-02-22 Impact factor: 17.173

8. Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.

Authors: Cristina Paulino; Yvonne Neldner; Andy Km Lam; Valeria Kalienkova; Janine Denise Brunner; Stephan Schenck; Raimund Dutzler
Journal: Elife Date: 2017-05-31 Impact factor: 8.140

9. Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A.

Authors: Andy Km Lam; Raimund Dutzler
Journal: Elife Date: 2018-10-12 Impact factor: 8.140

Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.

Review 1. TMEM16 proteins: unknown structure and confusing functions.

2. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.

Review 3. Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.

4. Calcium-dependent phospholipid scrambling by TMEM16F.

Review 5. Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.

6. Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.

7. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

8. Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.

9. Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A.

10. Molecular basis of PIP₂-dependent regulation of the Ca²⁺-activated chloride channel TMEM16A.

1. Allosteric modulation of alternatively spliced Ca²⁺-activated Cl^- channels TMEM16A by PI(4,5)P₂ and CaMKII.

2. Pharmacological Inhibition and Activation of the Ca²⁺ Activated Cl^- Channel TMEM16A.

3. Gating the pore of the calcium-activated chloride channel TMEM16A.

4. Specific PIP₂ binding promotes calcium activation of TMEM16A chloride channels.

5. Identification of a conserved drug binding pocket in TMEM16 proteins.

Review 6. Polymodal Control of TMEM16x Channels and Scramblases.