Alissa Cait1, Erick Cardenas1, Pedro A Dimitriu1, Nelly Amenyogbe1, Darlene Dai2, Jessica Cait3, Hind Sbihi2, Leah Stiemsma4, Padmaja Subbarao5, Piush J Mandhane6, Allen B Becker7, Theo J Moraes5, Malcolm R Sears8, Diana L Lefebvre8, Meghan B Azad9, Tobias Kollmann2, Stuart E Turvey10, William W Mohn11. 1. Department of Microbiology & Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. 2. Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 3. Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada. 4. Department of Microbiology & Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 5. Department of Pediatrics & Physiology, University of Toronto, Toronto, Ontario, Canada; Hospital for Sick Children, Toronto, Ontario, Canada. 6. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; School of Public Health, University of Alberta, Edmonton, Alberta, Canada. 7. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. 8. Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 9. Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Department of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. 10. Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: sturvey@cw.bc.ca. 11. Department of Microbiology & Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: wmohn@mail.ubc.ca.
Abstract
BACKGROUND: Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance. OBJECTIVE: We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children. METHODS: We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, before their developing allergic disease. RESULTS: We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production. CONCLUSIONS: Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.
BACKGROUND:Allergic disease is the most frequent chronic health issue in children and has been linked to early-life gut microbiomedysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance. OBJECTIVE: We sought to determine whether bacterial butyrate production in the gut during early infancy is protective against the development of atopic disease in children. METHODS: We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in humaninfants, before their developing allergic disease. RESULTS: We found that the microbiome of infants who went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production. CONCLUSIONS: Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against the development of allergies.
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