Lorena Cristina Curado Lopes1, João Felipe Mota2, Jonato Prestes3, Raquel Machado Schincaglia2, Debora Mendes Silva2, Nayara Pedatella Queiroz2, Ana Tereza Vaz de Souza Freitas2, Fábio Santos Lira4, Maria do Rosário Gondim Peixoto2. 1. Clinic Nutrition and Sports Research Laboratory, Faculty of Nutrition, Federal University of Goias, Goias, Brazil. Electronic address: lorenalopes.edfisica@hotmail.com. 2. Clinic Nutrition and Sports Research Laboratory, Faculty of Nutrition, Federal University of Goias, Goias, Brazil. 3. Postgraduation Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil. 4. Exercise and Immunometabolism Research Group, Post-Graduation Program in Movement Sciences, Department of Physical Education, Sports Research Group, Sao Paulo State University (IUNESP), Presidente Prudente, Sao Paulo, Brazil.
Abstract
OBJECTIVE: To compare the effects of high vs moderate loads of intradialytic resistance training (RT) on body composition, sarcopenia prevalence, functional capacity, inflammatory markers, and quality of life (QoL) in individuals on hemodialysis. DESIGN: A pilot randomized clinical trial. SETTING: Two hemodialysis centers. PARTICIPANTS: Individuals on hemodialysis (N=80; 51% men, aged 30-75y) in treatment for at least 3 months, adequately dialyzed (Kt/V≥1.2, where K is dialyzer clearance in mL/min, t is time, and V is volume of water) with vascular access via arteriovenous fistula. INTERVENTIONS: The 12 weeks of intradialytic RT was performed 3 times per week. The training groups were: high-load intradialytic group (HLG, 8-10 repetitions), moderate-load intradialytic group (MLG, 16-18 repetitions), and control group (CG, stretching exercise). The total training volume was equalized among training groups. MAIN OUTCOME MEASURES: Lean leg mass was assessed by a dual-energy x-ray absorptiometry; functional capacity was assessed by Short Physical Performance Battery and Timed Up and Go test; and QoL was assessed by Kidney Disease QoL Instrument, inflammatory markers, and sarcopenia. RESULTS: After the training period, the HLG increased lean leg mass compared with the CG. The HLG also displayed improvements in the pain and physical function domains. The skeletal muscle index and functional capacity increased in both RT protocols. The prevalence of sarcopenia was reduced 14.3% and 25% in the MLG and HLG, respectively, while there was an increase of 10% in the CG. No differences were observed in cytokines after intervention. CONCLUSIONS: High-load intradialytic RT was associated with gains in lean leg mass and QoL while functional capacity, appendicular muscle mass, and sarcopenia status were improved regardless of the RT load.
RCT Entities:
OBJECTIVE: To compare the effects of high vs moderate loads of intradialytic resistance training (RT) on body composition, sarcopenia prevalence, functional capacity, inflammatory markers, and quality of life (QoL) in individuals on hemodialysis. DESIGN: A pilot randomized clinical trial. SETTING: Two hemodialysis centers. PARTICIPANTS: Individuals on hemodialysis (N=80; 51% men, aged 30-75y) in treatment for at least 3 months, adequately dialyzed (Kt/V≥1.2, where K is dialyzer clearance in mL/min, t is time, and V is volume of water) with vascular access via arteriovenous fistula. INTERVENTIONS: The 12 weeks of intradialytic RT was performed 3 times per week. The training groups were: high-load intradialytic group (HLG, 8-10 repetitions), moderate-load intradialytic group (MLG, 16-18 repetitions), and control group (CG, stretching exercise). The total training volume was equalized among training groups. MAIN OUTCOME MEASURES: Lean leg mass was assessed by a dual-energy x-ray absorptiometry; functional capacity was assessed by Short Physical Performance Battery and Timed Up and Go test; and QoL was assessed by Kidney Disease QoL Instrument, inflammatory markers, and sarcopenia. RESULTS: After the training period, the HLG increased lean leg mass compared with the CG. The HLG also displayed improvements in the pain and physical function domains. The skeletal muscle index and functional capacity increased in both RT protocols. The prevalence of sarcopenia was reduced 14.3% and 25% in the MLG and HLG, respectively, while there was an increase of 10% in the CG. No differences were observed in cytokines after intervention. CONCLUSIONS: High-load intradialytic RT was associated with gains in lean leg mass and QoL while functional capacity, appendicular muscle mass, and sarcopenia status were improved regardless of the RT load.
Authors: Elizabeth C Lorenz; LaTonya J Hickson; Renee M Weatherly; Karin L Thompson; Heidi A Walker; Judy M Rasmussen; Tara L Stewart; James K Garrett; Hatem Amer; Cassie C Kennedy Journal: Clin Transplant Date: 2020-07-24 Impact factor: 2.863
Authors: Amelie Bernier-Jean; Nadim A Beruni; Nicola P Bondonno; Gabrielle Williams; Armando Teixeira-Pinto; Jonathan C Craig; Germaine Wong Journal: Cochrane Database Syst Rev Date: 2022-01-12