Dia Yang1, Lucy Robinson2, Christian Selinski1, Thalia Bajakian1, Christina Mejia3, Meera Nair Harhay1,2,4. 1. Department of Medicine, Drexel University College of Medicine, Philadelphia, PA. 2. Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, PA. 3. Department of Medicine, Division of Nephrology, Thomas Jefferson University, Philadelphia, PA. 4. Tower Health Transplant Institute, Tower Health System, West Reading, PA.
Abstract
PURPOSE OF REVIEW: Low physical function (PF) is common among individuals with end-stage kidney disease. In this review, we explore data on the impacts of PF on access to kidney transplantation (KT) and KT outcomes. We also discuss the latest interventions to improve PF in pre- and post-KT settings. RECENT FINDINGS: Many US KT programs measure PF or related constructs when assessing KT candidacy. Although carefully selected KT candidates with low PF can benefit from KT with respect to survival and quality of life, low PF decreases the likelihood of being listed for KT and increases the risk of adverse post-KT outcomes. Recent trials suggest that exercise is a promising strategy to improve PF among KT candidates and recipients. SUMMARY: PF is a potentially modifiable risk factor for adverse pre- and post-KT outcomes. Research is needed to determine the ideal PF metric for use in KT evaluations and interventions to improve PF.
PURPOSE OF REVIEW: Low physical function (PF) is common among individuals with end-stage kidney disease. In this review, we explore data on the impacts of PF on access to kidney transplantation (KT) and KT outcomes. We also discuss the latest interventions to improve PF in pre- and post-KT settings. RECENT FINDINGS: Many US KT programs measure PF or related constructs when assessing KT candidacy. Although carefully selected KT candidates with low PF can benefit from KT with respect to survival and quality of life, low PF decreases the likelihood of being listed for KT and increases the risk of adverse post-KT outcomes. Recent trials suggest that exercise is a promising strategy to improve PF among KT candidates and recipients. SUMMARY: PF is a potentially modifiable risk factor for adverse pre- and post-KT outcomes. Research is needed to determine the ideal PF metric for use in KT evaluations and interventions to improve PF.
Authors: Elisa J Gordon; Thomas Prohaska; Laura A Siminoff; Peter J Minich; Ashwini R Sehgal Journal: Am J Kidney Dis Date: 2005-04 Impact factor: 8.860
Authors: Marina Serper; Iwan Barankay; Sakshum Chadha; Justine Shults; Lauren S Jones; Kim M Olthoff; Peter P Reese Journal: Transpl Int Date: 2020-02-12 Impact factor: 3.782
Authors: Bertram L Kasiske; Nicholas Salkowski; Andrew Wey; David Zaun; Ajay K Israni; Jon J Snyder Journal: Transplantation Date: 2020-02 Impact factor: 4.939
Authors: Peter P Reese; Justine Shults; Roy D Bloom; Adam Mussell; Meera N Harhay; Peter Abt; Matthew Levine; Kirsten L Johansen; Jason T Karlawish; Harold I Feldman Journal: Am J Kidney Dis Date: 2015-07-07 Impact factor: 8.860