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Literature DB >> 31278148

Closing the gap of ubiquitin activation.

Manoj Kumar¹, Reuven Wiener².

Abstract

Year: 2019 PMID： 31278148 PMCID： PMC6681756 DOI： 10.1073/pnas.1909868116

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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22 in total

1. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Authors: Helen Walden; Michael S Podgorski; Danny T Huang; David W Miller; Rebecca J Howard; Daniel L Minor; James M Holton; Brenda A Schulman
Journal: Mol Cell Date: 2003-12 Impact factor: 17.970

2. Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.

Authors: Luisa Maria Lois; Christopher D Lima
Journal: EMBO J Date: 2005-01-20 Impact factor: 11.598

Review 3. The emerging complexity of protein ubiquitination.

Authors: David Komander
Journal: Biochem Soc Trans Date: 2009-10 Impact factor: 5.407

4. Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.

Authors: M W Lake; M M Wuebbens; K V Rajagopalan; H Schindelin
Journal: Nature Date: 2001-11-15 Impact factor: 49.962

5. Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.

Authors: Zeynep Tokgöz; Richard N Bohnsack; Arthur L Haas
Journal: J Biol Chem Date: 2006-04-04 Impact factor: 5.157

6. Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

Authors: John-Paul Bacik; John R Walker; Mohsin Ali; Aaron D Schimmer; Sirano Dhe-Paganon
Journal: J Biol Chem Date: 2010-04-05 Impact factor: 5.157

Closing the gap of ubiquitin activation.

1. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

2. Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.

Review 3. The emerging complexity of protein ubiquitination.

4. Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.

5. Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.

6. Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

7. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

8. Active site remodelling accompanies thioester bond formation in the SUMO E1.

Review 9. Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.

Review 10. The ubiquitin system, disease, and drug discovery.