Literature DB >> 3127647

Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids.

M R Berger1, D Schmähl.   

Abstract

The influence of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-hexadecylmercapto-2-methoxymethyl-rac-propyl-3-phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)-induced rat mammary carcinomas and of ET-18-OCH3 on 7,12-dimethylbenzanthracene (DMBA)-induced leukemias was investigated. Both agents effectively delayed MNU-induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low "immunomodulatory" doses. ET-18-OCH3 also significantly protected against leukemia development in DMBA-treated Long-Evans rats.

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Year:  1987        PMID： 3127647     DOI： 10.1007/bf02535559

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  13 in total

1.  Protection by the alkyllysophospholipid, 1-octadecyl-2-methoxy-rac-glycero-3-phosphocholine, but not by the retinoid etretinate against leukemia development in DMBA-treated Long-Evans rats.

Authors:  M R Berger; D Schmähl
Journal:  Cancer Lett       Date:  1986-01       Impact factor: 8.679

2.  Failure to detect mutagenic effects of anti-tumor alkyl-lysophospholipids.

Authors:  M T King; K Eckhardt; E Gocke; D Wild; W E Berdel; P G Munder
Journal:  Cancer Lett       Date:  1981-04       Impact factor: 8.679

3.  Influence of the alkyllysophospholipid ET-18-OCH3 on methylnitrosourea-induced rat mammary carcinomas.

Authors:  M R Berger; P G Munder; D Schmähl; O Westphal
Journal:  Oncology       Date:  1984       Impact factor: 2.935

4.  Effect of disulfiram on acetoxymethyl-methyl-nitrosamine-induced tumors in rats.

Authors:  M Habs; D Schmähl; H Kretzer
Journal:  Oncology       Date:  1981       Impact factor: 2.935

5.  Experiments on the influence of an aromatic retinoid on the chemical carcinogenesis induced by N-nitroso-methyl benzylamine in rats.

Authors:  D Schmähl; M Habs
Journal:  Arzneimittelforschung       Date:  1981

6.  Alkyl-lysophospholipids lack influence on the occurrence of radiation-induced lymphomas and AKR-leukemia.

Authors:  W E Berdel; A Luz; J Rastetter; U Fink; W Gössner; O Messerschmidt
Journal:  Cancer Lett       Date:  1983-09       Impact factor: 8.679

7.  Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna).

Authors:  N Brock; J Pohl; J Stekar; W Scheef
Journal:  Eur J Cancer Clin Oncol       Date:  1982-12

8.  Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.

Authors:  K Ormstad; S Orrenius; T Låstbom; N Uehara; J Pohl; J Stekar; N Brock
Journal:  Cancer Res       Date:  1983-01       Impact factor: 12.701

9.  Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats.

Authors:  D Schmähl; F W Krüger; M Habs; B Diehl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-03-19

10.  Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in Long Evans rats.

Authors:  W J Zeller; M Berger; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553
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  4 in total

1.  Structure-function relationships of alkyl-lysophospholipid analogs in selective antitumor activity.

Authors:  W R Vogler; A C Olson; J Hajdu; M Shoji; R Raynor; J F Kuo
Journal:  Lipids       Date:  1993-06       Impact factor: 1.880

2.  Cytotoxicity of ether phospholipid BM 41.440 on neuroblastoma cells.

Authors:  R Girgert; P Schweizer; I Bock; R Narr; G Bruchelt
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

3.  Antitumor activity of Ilmofosine (BM 41.440) in the 3Lewis-lung carcinoma model.

Authors:  D B Herrmann; H G Opitz; P G Munder
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

Review 4.  Membrane-interactive lipids as experimental anticancer drugs.

Authors:  W E Berdel
Journal:  Br J Cancer       Date:  1991-08       Impact factor: 7.640
  4 in total

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