Literature DB >> 3127585

The cost effectiveness of auranofin: results of a randomized clinical trial.

M S Thompson1, J L Read, H C Hutchings, M Paterson, E D Harris.   

Abstract

In a 6-month randomized trial at 14 sites, the cost effectiveness of auranofin (AF) treatment for patients with rheumatoid arthritis was gauged in comparison with placebo. Measures of global health and of impacts on daily life suggest that the benefits of disease modification outweigh adverse effects after 4 and 6 months of treatment (p less than 0.01), with negligible differences between placebo and treated patients after 1 and 2 months. Additional medical costs directly associated with AF treatment amounted to $778/patient annually. Observed differences in less direct medical costs, help received, and earnings were not statistically significant.

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Year:  1988        PMID: 3127585

Source DB:  PubMed          Journal:  J Rheumatol        ISSN: 0315-162X            Impact factor:   4.666


  18 in total

Review 1.  Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II.

Authors:  G Samsa; D Edelman; M L Rothman; G R Williams; J Lipscomb; D Matchar
Journal:  Pharmacoeconomics       Date:  1999-02       Impact factor: 4.981

2.  [Performance appraisal of internal health services].

Authors:  A Boutat; Y Eggli; P Frutiger
Journal:  Soz Praventivmed       Date:  1992

Review 3.  Statistical versus quantitative significance in the socioeconomic evaluation of medicines.

Authors:  B J O'Brien; M F Drummond
Journal:  Pharmacoeconomics       Date:  1994-05       Impact factor: 4.981

Review 4.  Statistical analysis in pharmacoeconomic studies. A review of current issues and standards.

Authors:  D Coyle
Journal:  Pharmacoeconomics       Date:  1996-06       Impact factor: 4.981

Review 5.  Measuring performance in clinical rheumatology.

Authors:  D L Scott; I Haslock
Journal:  Ann Rheum Dis       Date:  1990-01       Impact factor: 19.103

Review 6.  International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review.

Authors:  Hubertus Rosery; Rito Bergemann; Stefanie Maxion-Bergemann
Journal:  Pharmacoeconomics       Date:  2005       Impact factor: 4.981

Review 7.  How can quality of life researchers make their work more useful to health workers and their patients?

Authors:  Gordon Guyatt; Holger Schunemann
Journal:  Qual Life Res       Date:  2007-05-26       Impact factor: 4.147

Review 8.  The costs of rheumatoid arthritis.

Authors:  S H Allaire; M J Prashker; R F Meenan
Journal:  Pharmacoeconomics       Date:  1994-12       Impact factor: 4.981

9.  Intra-articular steroids: confounder of clinical trials.

Authors:  H G Taylor; P D Fowler; M J David; P T Dawes
Journal:  Clin Rheumatol       Date:  1991-03       Impact factor: 2.980

10.  Randomized trial of switching rheumatoid arthritis patients in remission with injectable gold to auranofin.

Authors:  P E Prete; J Zane; M Krailo; M Bulanowski
Journal:  Clin Rheumatol       Date:  1994-03       Impact factor: 2.980

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