Literature DB >> 3127235

Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat.

E C Griffiths1, N J Rothwell, M J Stock.   

Abstract

Acute or chronic injection of RX 77,368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain. Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO2. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat.

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Year:  1988        PMID： 3127235     DOI： 10.1007/bf01960238

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  An automatic, closed-circuit oxygen consumption apparatus for small animals.

Authors:  M J Stock
Journal:  J Appl Physiol       Date:  1975-11       Impact factor: 3.531

2.  Synthesis of thyrotropin-releasing hormone analogues. 2. Tripeptides structurally greatly differing from TRH with high central nervous system activity.

Authors:  T Szirtes; L Kisfaludy; E Pálosi; L Szporny
Journal:  J Med Chem       Date:  1986-09       Impact factor: 7.446

3.  Effects of thyrotropin-releasing hormone and cyclo-histidine-proline on the homeothermic development of neonatal rats.

Authors:  T Sato; T Kato; C Miyamori; S Kajiwara; A Murata; E Imura; N Sakura; T Hashimoto
Journal:  Acta Endocrinol (Copenh)       Date:  1986-10

4.  Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.

Authors:  C B Nemeroff; P W Kalivas; R N Golden; A J Prange
Journal:  Pharmacol Ther       Date:  1984       Impact factor: 12.310

Review 5.  Thyrotropin-releasing hormone.

Authors:  I M Jackson
Journal:  N Engl J Med       Date:  1982-01-21       Impact factor: 91.245

6.  Effects of diet and acute noradrenaline treatment on brown adipose tissue development and mitochondrial purine-nucleotide binding.

Authors:  S L Brooks; N J Rothwell; M J Stock
Journal:  Q J Exp Physiol       Date:  1982-04

7.  Thyrotropin-releasing hormone (TRH)-induced hyperthermia and behavioral excitation in rabbits.

Authors:  A Horita; M A Carino
Journal:  Psychopharmacol Commun       Date:  1975

8.  Thyrotropin releasing hormone-induced hyperthermia in mice: possible involvement of adrenal and pituitary glands.

Authors:  G Boschi; T Nomoto; R Rips
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

9.  The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin.

Authors:  E C Griffiths; P Slater; P S Widdowson
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

10.  Influence of thyroid hormone on diet-induced thermogenesis in the rat.

Authors:  N J Rothwell; M E Saville; M J Stock; M G Wyllie
Journal:  Horm Metab Res       Date:  1983-08       Impact factor: 2.936
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  4 in total

Review 1.  Central nervous system regulation of brown adipose tissue.

Authors:  Shaun F Morrison; Christopher J Madden
Journal:  Compr Physiol       Date:  2014-10       Impact factor: 9.090

Review 2.  Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.

Authors:  Shaun F Morrison; Christopher J Madden; Domenico Tupone
Journal:  Cell Metab       Date:  2014-03-13       Impact factor: 27.287

3.  Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance.

Authors:  N M Semjonous; K L Smith; J R C Parkinson; D J L Gunner; Y-L Liu; K G Murphy; M A Ghatei; S R Bloom; C J Small
Journal:  Int J Obes (Lond)       Date:  2009-06-02       Impact factor: 5.095

4.  Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus.

Authors:  Zhigang Shi; Nicole E Pelletier; Jennifer Wong; Baoxin Li; Andrei D Sdrulla; Christopher J Madden; Daniel L Marks; Virginia L Brooks
Journal:  Elife       Date:  2020-06-15       Impact factor: 8.140
  4 in total

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