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Literature DB >> 31268603

Of seeds and supplements: structural insights into extended microRNA-target pairing.

Abstract

Metazoan micro(mi) RNAs guide Argonaute proteins to their targets via perfect pairing to the seed region, located near the 5' end of the miRNA. In this issue of The EMBO Journal, Sheu-Gruttadauria et al report the crystal structure of human Argonaute 2 in complex with both a miRNA and target RNA and show that miRNA 3' supplementary nucleotides can increase target affinity and may contribute more to miRNA-mediated silencing than is currently appreciated.

Entities: Gene Species

Mesh：

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Year: 2019 PMID： 31268603 PMCID： PMC6600611 DOI： 10.15252/embj.2019102477

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

12 in total

1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.

Authors: Ryan D Morin; Michael D O'Connor; Malachi Griffith; Florian Kuchenbauer; Allen Delaney; Anna-Liisa Prabhu; Yongjun Zhao; Helen McDonald; Thomas Zeng; Martin Hirst; Connie J Eaves; Marco A Marra
Journal: Genome Res Date: 2008-02-19 Impact factor: 9.043

Of seeds and supplements: structural insights into extended microRNA-target pairing.

1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.

2. Of seeds and supplements: structural insights into extended microRNA-target pairing.

3. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides.

4. Structural basis for microRNA targeting.

5. Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2.

6. Most mammalian mRNAs are conserved targets of microRNAs.

7. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.

8. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties.

Review 9. MicroRNAs: target recognition and regulatory functions.

10. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides.

1. Of seeds and supplements: structural insights into extended microRNA-target pairing.

2. Computational meta-analysis of ribosomal RNA fragments: potential targets and interaction mechanisms.