Literature DB >> 31264495

New oral liposomal vitamin C formulation: properties and bioavailability.

Maciej Łukawski1, Paulina Dałek1,2, Tomasz Borowik2, Aleksander Foryś3, Marek Langner1,2, Wojciech Witkiewicz4, Magdalena Przybyło1,2.   

Abstract

Vitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, the efficient delivery is critical for the maintenance of body homeostasis. Vitamin C pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In the paper, we present the new liposomal formulation of vitamin C free of harmful organic solvents. The formulation was quantitatively characterized with respect to its chemically composition and nano-structuring. The vitamin C accessibility to cells from the formulation was evaluated using evidence derived from experiments performed on cell cultures. Finally, the enhanced bioavailability of vitamin C from the formulation was demonstrated in the medical experiment.

Entities:  

Keywords:  Liposome; bioavailability; efficacy; stability; vitamin C

Mesh:

Substances:

Year:  2019        PMID: 31264495     DOI: 10.1080/08982104.2019.1630642

Source DB:  PubMed          Journal:  J Liposome Res        ISSN: 0898-2104            Impact factor:   3.648


  7 in total

Review 1.  Vitamin C and Cardiovascular Disease: An Update.

Authors:  Marco B Morelli; Jessica Gambardella; Vanessa Castellanos; Valentina Trimarco; Gaetano Santulli
Journal:  Antioxidants (Basel)       Date:  2020-12-03

Review 2.  Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications.

Authors:  Victoria Dupuis; Constantin Cerbu; Lucjan Witkowski; Adrian-Valentin Potarniche; Maria Cristina Timar; Monika Żychska; Cristina M Sabliov
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.419

3.  The Membrane Electrical Potential and Intracellular pH as Factors Influencing Intracellular Ascorbate Concentration and Their Role in Cancer Treatment.

Authors:  Mateusz Gąbka; Paulina Dałek; Magdalena Przybyło; Daniel Gackowski; Ryszard Oliński; Marek Langner
Journal:  Cells       Date:  2021-10-30       Impact factor: 6.600

4.  Surface-engineered liposomal particles of calcium ascorbate with fenugreek galactomannan enhanced the oral bioavailability of ascorbic acid: a randomized, double-blinded, 3-sequence, crossover study.

Authors:  Ashil Joseph; Dinesh Kumar; Abhilash Balakrishnan; Prasanth Shanmughan; Balu Maliakel; Krishnakumar Im
Journal:  RSC Adv       Date:  2021-11-26       Impact factor: 4.036

5.  Liposomal Mineral Absorption: A Randomized Crossover Trial.

Authors:  Grant M Tinsley; Patrick S Harty; Matthew T Stratton; Madelin R Siedler; Christian Rodriguez
Journal:  Nutrients       Date:  2022-08-13       Impact factor: 6.706

6.  Formulation of Piperine-Chitosan-Coated Liposomes: Characterization and In Vitro Cytotoxic Evaluation.

Authors:  Syed Sarim Imam; Sultan Alshehri; Mohammad A Altamimi; Afzal Hussain; Wajhul Qamar; Sadaf Jamal Gilani; Ameeduzzafar Zafar; Nabil K Alruwaili; Saleh Alanazi; Bjad K Almutairy
Journal:  Molecules       Date:  2021-05-29       Impact factor: 4.411

Review 7.  On the physiological and cellular homeostasis of ascorbate.

Authors:  Magdalena Przybyło; Marek Langner
Journal:  Cell Mol Biol Lett       Date:  2020-05-29       Impact factor: 5.787

  7 in total

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