Literature DB >> 31264145

Fatal poisoning with diethylene glycol in an unusual setting.

Daniel Wittschieber1,2, Katrin Heuberger3, Ronald Schulz3, Helga Köhler3, Karin Varchmin-Schultheiß3.   

Abstract

Morphological findings in cases of intoxication are relatively rare in forensic pathology. In this article we report on a 26-year-old man who drank clear fluid from a tequila bottle that was given to him by a friend. Afterwards, the clear fluid was assumed to be smoke fluid containing diethylene glycol (DEG). The man died eight days later. Macroscopic and microscopic examination of the kidneys and the liver at forensic autopsy revealed findings typical of a DEG intoxication. In addition, the clinical course showed the typical triphasic pattern of symptoms. Toxicological analysis confirmed the presence of DEG in both the original smoke fluid and the tequila bottle. In conclusion, death was due to fatal intoxication by DEG. While most DEG intoxications have been mass poisoning incidents attributed to pharmaceutical products, the present case describes an unusual example of a single decedent.

Entities:  

Keywords:  Diethylene glycol; Fatal intoxication; Forensic histology; Kidney necrosis

Year:  2019        PMID: 31264145     DOI: 10.1007/s12024-019-00123-4

Source DB:  PubMed          Journal:  Forensic Sci Med Pathol        ISSN: 1547-769X            Impact factor:   2.007


  8 in total

1.  Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol.

Authors:  Lauren M Besenhofer; Marie C McLaren; Brian Latimer; Michael Bartels; Mark J Filary; Adam W Perala; Kenneth E McMartin
Journal:  Toxicol Sci       Date:  2011-07-29       Impact factor: 4.849

Review 2.  Delayed neurological sequelae from ethylene glycol, diethylene glycol and methanol poisonings.

Authors:  Nandi J Reddy; Madhuri Sudini; Lionel D Lewis
Journal:  Clin Toxicol (Phila)       Date:  2010-12       Impact factor: 4.467

3.  Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol.

Authors:  Luis A Ferrari; Leda Giannuzzi
Journal:  Forensic Sci Int       Date:  2005-10-04       Impact factor: 2.395

4.  Clinical, laboratory, diagnostic, and histopathologic features of diethylene glycol poisoning--Panama, 2006.

Authors:  Nestor R Sosa; Giselle M Rodriguez; Joshua G Schier; James J Sejvar
Journal:  Ann Emerg Med       Date:  2014-01-15       Impact factor: 5.721

5.  Diethylene glycol: widely used solvent presents serious poisoning potential.

Authors:  Jeanna M Marraffa; Michael G Holland; Christine M Stork; Christopher D Hoy; Michael J Hodgman
Journal:  J Emerg Med       Date:  2007-11-19       Impact factor: 1.484

6.  Ethylene and diethylene glycol toxicity.

Authors:  C L Winek; D P Shingleton; S P Shanor
Journal:  Clin Toxicol       Date:  1978       Impact factor: 4.467

Review 7.  Diethylene glycol poisoning.

Authors:  Leo J Schep; Robin J Slaughter; Wayne A Temple; D Michael G Beasley
Journal:  Clin Toxicol (Phila)       Date:  2009-07       Impact factor: 4.467

Review 8.  Neurological manifestation of recreational fatal and near-fatal diethylene glycol poisonings: case series and review of literature.

Authors:  Yahia Zakaria Bashier Imam; Saadat Kamran; Hanfa Karim; Osama Elalamy; Tageldin Sokrab; Yasir Osman; Dirk Deleu
Journal:  Medicine (Baltimore)       Date:  2014-08       Impact factor: 1.889

  8 in total

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