Literature DB >> 31262860

Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment.

Judyta Zabielska1, Tomasz Sledzinski2, Ewa Stelmanska1.   

Abstract

Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of proliferation in a range of cancer cell types both in vitro and in vivo. The exact mechanism of this phenomenon is being investigated, and the most important findings are presented in this review. Copyright
© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  ACAT; Cholesterol metabolism; avasimibe; cancer; review

Mesh：

Substances：

Year:  2019        PMID： 31262860     DOI： 10.21873/anticanres.13482

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  7 in total

Review 1.  Development of Immunotherapy Strategies Targeting Tumor Microenvironment Is Fiercely Ongoing.

Authors:  Rilan Bai; Jiuwei Cui
Journal:  Front Immunol       Date:  2022-06-27       Impact factor: 8.786

Review 2.  The Pathophysiological Role of CoA.

Authors:  Aleksandra Czumaj; Sylwia Szrok-Jurga; Areta Hebanowska; Jacek Turyn; Julian Swierczynski; Tomasz Sledzinski; Ewa Stelmanska
Journal:  Int J Mol Sci       Date:  2020-11-28       Impact factor: 5.923

3.  Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover.

Authors:  Nikki L Raftopulos; Tinashe C Washaya; Andreas Niederprüm; Antonia Egert; Mariam F Hakeem-Sanni; Bianca Varney; Atqiya Aishah; Mariya L Georgieva; Ellinor Olsson; Diandra Z Dos Santos; Zeyad D Nassar; Blake J Cochran; Shilpa R Nagarajan; Meghna S Kakani; Jordan F Hastings; David R Croucher; Kerry-Anne Rye; Lisa M Butler; Thomas Grewal; Andrew J Hoy
Journal:  Cancer Metab       Date:  2022-01-15

Review 4.  Contradictory roles of lipid metabolism in immune response within the tumor microenvironment.

Authors:  Weina Yu; Qingyang Lei; Li Yang; Guohui Qin; Shasha Liu; Dan Wang; Yu Ping; Yi Zhang
Journal:  J Hematol Oncol       Date:  2021-11-06       Impact factor: 17.388

5.  In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size.

Authors:  Nivas Shyamala; Chaitra Lava Kongettira; Kaushik Puranam; Keerthi Kupsal; Ramanjaneyulu Kummari; Chiranjeevi Padala; Surekha Rani Hanumanth
Journal:  Sci Rep       Date:  2022-03-04       Impact factor: 4.996

Review 6.  The Integration of Metabolomics with Other Omics: Insights into Understanding Prostate Cancer.

Authors:  Eleazer P Resurreccion; Ka-Wing Fong
Journal:  Metabolites       Date:  2022-05-27

Review 7.  Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi.

Authors:  Efaq Noman; Muhanna Mohammed Al-Shaibani; Muhammed Adnan Bakhrebah; Reyad Almoheer; Mohammed Al-Sahari; Adel Al-Gheethi; Radin Maya Saphira Radin Mohamed; Yaaser Qaeed Almulaiky; Wesam Hussain Abdulaal
Journal:  J Fungi (Basel)       Date:  2021-05-30
  7 in total

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