Literature DB >> 31262815

Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.

Jonathan Zirin1, Xiaochun Ni1, Laura M Sack1, Donghui Yang-Zhou1, Yanhui Hu1, Roderick Brathwaite1, Martha L Bulyk1,2, Stephen J Elledge1,2,3, Norbert Perrimon4,3.   

Abstract

Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of Drosophila genes that are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes required for cellular biosynthesis. Among these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of Myc growth control in Drosophila and found that their pharmacologic inhibition is sufficient to kill MYC-overexpressing human cells, indicating that aaRS inhibitors might be used to selectively target MYC-driven cancers. We suggest a general principle in which oncogenic increases in cellular biosynthesis sensitize cells to disruption of protein homeostasis.

Entities:  

Keywords:  Drosophila; MYC; cancer; nucleolus; tRNA synthetase

Year:  2019        PMID： 31262815      PMCID： PMC6642371          DOI： 10.1073/pnas.1821863116

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  44 in total

1.  X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.

Authors:  Satish K Nair; Stephen K Burley
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

Review 2.  Transcription factors as targets for cancer therapy.

Authors:  James E Darnell
Journal:  Nat Rev Cancer       Date:  2002-10       Impact factor: 60.716

3.  Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.

Authors:  H A Coller; C Grandori; P Tamayo; T Colbert; E S Lander; R N Eisenman; T R Golub
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

4.  Drosophila myc regulates cellular growth during development.

Authors:  L A Johnston; D A Prober; B A Edgar; R N Eisenman; P Gallant
Journal:  Cell       Date:  1999-09-17       Impact factor: 41.582

Review 5.  MYC oncogenes and human neoplastic disease.

Authors:  C E Nesbit; J M Tersak; E V Prochownik
Journal:  Oncogene       Date:  1999-05-13       Impact factor: 9.867

6.  Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.

Authors:  Feng Li; Yunyue Wang; Karen I Zeller; James J Potter; Diane R Wonsey; Kathryn A O'Donnell; Jung-Whan Kim; Jason T Yustein; Linda A Lee; Chi V Dang
Journal:  Mol Cell Biol       Date:  2005-07       Impact factor: 4.272

7.  A role for c-Myc in the regulation of ribosomal RNA processing.

Authors:  Isabel Schlosser; Michael Hölzel; Marlies Mürnseer; Helmut Burtscher; Ulrich H Weidle; Dirk Eick
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

8.  Genomic targets of the human c-Myc protein.

Authors:  Paula C Fernandez; Scott R Frank; Luquan Wang; Marianne Schroeder; Suxing Liu; Jonathan Greene; Andrea Cocito; Bruno Amati
Journal:  Genes Dev       Date:  2003-04-14       Impact factor: 11.361

9.  Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

Authors:  Aurelio A Teleman; Ville Hietakangas; Aram C Sayadian; Stephen M Cohen
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

10.  Drosophila growth and development in the absence of dMyc and dMnt.

Authors:  Sarah B Pierce; Cynthia Yost; Sarah A R Anderson; Erin M Flynn; Jeffrey Delrow; Robert N Eisenman
Journal:  Dev Biol       Date:  2007-12-27       Impact factor: 3.582
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  6 in total

1.  MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.

Authors:  Tessa M Popay; Jing Wang; Clare M Adams; Gregory Caleb Howard; Simona G Codreanu; Stacy D Sherrod; John A McLean; Lance R Thomas; Shelly L Lorey; Yuichi J Machida; April M Weissmiller; Christine M Eischen; Qi Liu; William P Tansey
Journal:  Elife       Date:  2021-01-08       Impact factor: 8.140

2.  The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.

Authors:  Margaret E Torrence; Michael R MacArthur; Aaron M Hosios; Alexander J Valvezan; John M Asara; James R Mitchell; Brendan D Manning
Journal:  Elife       Date:  2021-03-01       Impact factor: 8.140

3.  Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes.

Authors:  Akira Terakawa; Yanhui Hu; Toshiya Kokaji; Katsuyuki Yugi; Keigo Morita; Satoshi Ohno; Yifei Pan; Yunfan Bai; Andrey A Parkhitko; Xiaochun Ni; John M Asara; Martha L Bulyk; Norbert Perrimon; Shinya Kuroda
Journal:  iScience       Date:  2022-04-08

4.  The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.

Authors:  David A Anderson; Theresa L Murphy; Robert N Eisenman; Kenneth M Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  2020-02-18       Impact factor: 11.205

5.  YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling.

Authors:  Cheng Zhang; Xiaoting Lin; Qian Zhao; Yakun Wang; Fangli Jiang; Congcong Ji; Yanyan Li; Jing Gao; Jian Li; Lin Shen
Journal:  J Cancer Res Clin Oncol       Date:  2020-01-08       Impact factor: 4.553

Review 6.  Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer.

Authors:  Francesca Destefanis; Valeria Manara; Paola Bellosta
Journal:  Int J Mol Sci       Date:  2020-06-05       Impact factor: 5.923
  6 in total

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