Literature DB >> 3125959

Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes.

T W Glover1, J F Coyle-Morris, F P Li, R S Brown, C S Berger, R M Gemmill, F Hecht.   

Abstract

The common fragile site at 3p14(FRA3B) is cytogenetically close to the positions of translocation and deletion breakpoints frequently observed in renal cell carcinoma (RCC) and small cell carcinoma of the lung. Possible involvement of this fragile site in the familial RCC t(3;8)(p14.2;q24.1) was investigated. Expression of FRA3B, induced by treatment of lymphocytes with aphidicolin, is altered by the translocation. These results suggest that the fragile site is very close to, if not coincident with, the translocation breakpoint.

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Year:  1988        PMID： 3125959     DOI： 10.1016/0165-4608(88)90013-1

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  7 in total

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3.  Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation.

Authors:  Takema Kato; Colleen P Franconi; Molly B Sheridan; April M Hacker; Hidehito Inagakai; Thomas W Glover; Martin F Arlt; Harry A Drabkin; Robert M Gemmill; Hiroki Kurahashi; Beverly S Emanuel
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Review 5.  Fhit tumor suppressor: guardian of the preneoplastic genome.

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6.  FHIT gene alterations in head and neck squamous cell carcinomas.

Authors:  L Virgilio; M Shuster; S M Gollin; M L Veronese; M Ohta; K Huebner; C M Croce
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Review 7.  Fragile histidine triad protein: structure, function, and its association with tumorogenesis.

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  7 in total

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