Literature DB >> 31258805

CEREBELLAR ATAXIA AS A PRESENTING FEATURE OF HYPOTHYROIDISM.

S K Kotwal1, S Kotwal2, R Gupta1, J B Singh1, A Mahajan1.   

Abstract

CONTEXT: Besides its typical features, hypothyroidism comes to notice sometimes with neurologic features like reversible cerebellar ataxia, dementia, peripheral neuropathy, coma, etc. Therefore hypothyroidism should be suspected in all cases of cerebellar ataxia, as it is easily treatable.
OBJECTIVE: Here we illustrate a case of hypothyroidism initially reported with cerebellar ataxia. CASE REPORT: A 40 year-old male presented with history of gait-ataxia. His investigations revealed frank primary hypothyroidism with positive anti-TPO antibody. The patient was put on thyroxine and he improved completely within eight weeks.
CONCLUSIONS: This case report emphasizes that hypothyroidism can present with ataxia as one of the initial features. Therefore, hypothyroidism should be considered in all cases of cerebellar ataxia as it is a reversible cause of ataxia.

Entities:  

Keywords:  cerebellar ataxia; hypothyroidism; thyroxine

Year:  2016        PMID: 31258805      PMCID: PMC6586745          DOI: 10.4183/aeb.2016.77

Source DB:  PubMed          Journal:  Acta Endocrinol (Buchar)        ISSN: 1841-0987            Impact factor:   0.877


  13 in total

1.  Hashimoto's encephalopathy presenting with progressive cerebellar ataxia.

Authors:  H Nakagawa; M Yoneda; A Fujii; K Kinomoto; M Kuriyama
Journal:  J Neurol Neurosurg Psychiatry       Date:  2007-02       Impact factor: 10.154

2.  Cerebellar syndrome in myxoedema revisited: a published case with carcinomatosis and multiple system atrophy at necropsy.

Authors:  N Quinn; R O Barnard; R E Kelly
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-07       Impact factor: 10.154

3.  Concentrations of thyrotropin-releasing hormone in the brain of ataxic mice.

Authors:  T Mitsuma; K Adachi; K Ando
Journal:  J Neurol Sci       Date:  1986-09       Impact factor: 3.181

4.  [Cerebellar ataxia due to hypothyroidism in adults (case report)].

Authors:  C H Hammar; F Regli
Journal:  Dtsch Med Wochenschr       Date:  1975-07-11       Impact factor: 0.628

5.  Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis.

Authors:  M Selim; D A Drachman
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-07       Impact factor: 10.154

6.  Cerebellar-ataxic syndrome in children and adolescents with hypothyroidism under treatment.

Authors:  J Wiebel
Journal:  Acta Paediatr Scand       Date:  1976-03

7.  Subclinical hypothyroidism presenting with gait abnormality.

Authors:  Bengt Edvardsson; Staffan Persson
Journal:  Neurologist       Date:  2010-03       Impact factor: 1.398

Review 8.  Thyrotropin-releasing hormone (TRH) in the cerebellum.

Authors:  Nobuyuki Shibusawa; Koshi Hashimoto; Masanobu Yamada
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

Review 9.  Current perspectives on the role of thyroid hormone in growth and development of cerebellum.

Authors:  Noriyuki Koibuchi; Hisaka Jingu; Toshiharu Iwasaki; William W Chin
Journal:  Cerebellum       Date:  2003       Impact factor: 3.847

10.  Steroid-responsive encephalopathy in autoimmune thyroiditis: Clinical spectrum and MRI observations in three cases.

Authors:  K Dinkar; Sanjib Sinha; A B Taly; P S Bindu; R D Bharath
Journal:  Ann Indian Acad Neurol       Date:  2011-07       Impact factor: 1.383

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