Literature DB >> 20220447

Subclinical hypothyroidism presenting with gait abnormality.

Bengt Edvardsson1, Staffan Persson.   

Abstract

Subclinical thyroid disease is a common disorder, particularly in middle-aged and elderly individuals. Some patients with manifest hypothyroidism complain of unsteadiness of gait. The management of subclinical hypothyroidism is controversial. A 61-year-old man presented with a mild gait abnormality. He walked unsteadily on a broad base. Examination revealed a slight cerebellar ataxic gait. Laboratory evaluation showed elevated levels of thyroid-stimulating hormone. Serum free thyroxine was normal and thyroglobulin antibodies were present. Computer tomography of the patient's head was normal, as were other investigations. The patient responded rapidly to thyroxin treatment with resolution of the gait disturbance. A laboratory evaluation of thyroid function should be performed in similar cases, and treatment should be initiated when called for. Subclinical hypothyroidism can present as a cerebellar ataxic gait.

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Year:  2010        PMID: 20220447     DOI: 10.1097/NRL.0b013e3181be6fdb

Source DB:  PubMed          Journal:  Neurologist        ISSN: 1074-7931            Impact factor:   1.398


  6 in total

Review 1.  Cerebellar Syndrome Associated with Thyroid Disorders.

Authors:  Tommaso Ercoli; Giovanni Defazio; Antonella Muroni
Journal:  Cerebellum       Date:  2019-10       Impact factor: 3.847

2.  CEREBELLAR ATAXIA AS A PRESENTING FEATURE OF HYPOTHYROIDISM.

Authors:  S K Kotwal; S Kotwal; R Gupta; J B Singh; A Mahajan
Journal:  Acta Endocrinol (Buchar)       Date:  2016 Jan-Mar       Impact factor: 0.877

3.  Cerebellar Ataxia from Multiple Potential Causes: Hypothyroidism, Hashimoto's Thyroiditis, Thalamic Stimulation, and Essential Tremor.

Authors:  Natalya Shneyder; Mark K Lyons; Erika Driver-Dunckley; Virgilio Gerald H Evidente
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-03-22

Review 4.  Endocrine disorders and the neurologic manifestations.

Authors:  Jeesuk Yu
Journal:  Ann Pediatr Endocrinol Metab       Date:  2014-12-31

5.  Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis.

Authors:  Alicia Baumgartner; Natalia Stepien; Lisa Mayr; Sibylle Madlener; Christian Dorfer; Maria T Schmook; Tatjana Traub-Weidinger; Daniela Lötsch-Gojo; Dominik Kirchhofer; Dominik Reisinger; Cora Hedrich; Saleha Arshad; Stefan Irschik; Heidrun Boztug; Gernot Engstler; Marie Bernkopf; Fikret Rifatbegovic; Christoph Höller; Irene Slavc; Walter Berger; Leonhard Müllauer; Christine Haberler; Amedeo A Azizi; Andreas Peyrl; Johannes Gojo
Journal:  J Pers Med       Date:  2021-04-12

6.  Gait patterns associated with thyroid function: The Rotterdam Study.

Authors:  Arjola Bano; Layal Chaker; Sirwan K L Darweesh; Tim I M Korevaar; Francesco U S Mattace-Raso; Abbas Dehghan; Oscar H Franco; Jos N van der Geest; M Arfan Ikram; Robin P Peeters
Journal:  Sci Rep       Date:  2016-12-14       Impact factor: 4.379

  6 in total

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