Agnieszka Maciejewska-Skrendo1, Andrzej Pawlik2, Marek Sawczuk3, Monika Rać4, Andrzej Kusak5, Krzysztof Safranow4, Violetta Dziedziejko4. 1. Unit of Biology, Ecology and Sports Medicine, Chair of Natural Sciences, Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdansk, Poland. 2. Department of Physiology, Pomeranian Medical University, Szczecin, Poland. Electronic address: pawand@poczta.onet.pl. 3. Laboratory of Physical Medicine, Chair of Sport, Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland. 4. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland. 5. Department of Cardiology, County Hospital, Szczecin, Poland.
Abstract
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) include the nuclear receptor superfamily of ligand-activated transcription factors involved in several metabolic processes, including carbohydrate and lipid metabolism. MATERIAL AND METHODS: In this study we examined PPARA: rs4253778, rs1800206, PPARD: rs2267668, rs2016520, rs1053049, PPARG rs1801282 and PPARGC1A rs8192678 polymorphisms in patients with unstable angina. This study included 246 patients with unstable angina confirmed by coronary angiography (defined by >70% stenosis in at least one major coronary artery) and 189 healthy controls. RESULTS: We observed statistically significant difference in distribution of PPARG rs1801282 genotypes and alleles between patients and control group. Among patients there was the increased frequency of CG and GG genotypes and G alleles. The association between PPARG rs1801282 G allele and unstable angina was confirmed in multivariate regression analysis. There were no statistically significant differences in the distributions of other studied polymorphisms between patients with unstable angina and the control group. CONCLUSIONS: The results of our study suggest the association between PPARG rs1801282 G allele and unstable angina in Polish population.
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) include the nuclear receptor superfamily of ligand-activated transcription factors involved in several metabolic processes, including carbohydrate and lipid metabolism. MATERIAL AND METHODS: In this study we examined PPARA: rs4253778, rs1800206, PPARD: rs2267668, rs2016520, rs1053049, PPARGrs1801282 and PPARGC1Ars8192678 polymorphisms in patients with unstable angina. This study included 246 patients with unstable angina confirmed by coronary angiography (defined by >70% stenosis in at least one major coronary artery) and 189 healthy controls. RESULTS: We observed statistically significant difference in distribution of PPARGrs1801282 genotypes and alleles between patients and control group. Among patients there was the increased frequency of CG and GG genotypes and G alleles. The association between PPARGrs1801282 G allele and unstable angina was confirmed in multivariate regression analysis. There were no statistically significant differences in the distributions of other studied polymorphisms between patients with unstable angina and the control group. CONCLUSIONS: The results of our study suggest the association between PPARGrs1801282 G allele and unstable angina in Polish population.
Authors: Tessa Schillemans; Vinicius Tragante; Buamina Maitusong; Bruna Gigante; Sharon Cresci; Federica Laguzzi; Max Vikström; Mark Richards; Anna Pilbrow; Vicky Cameron; Luisa Foco; Robert N Doughty; Pekka Kuukasjärvi; Hooman Allayee; Jaana A Hartiala; W H Wilson Tang; Leo-Pekka Lyytikäinen; Kjell Nikus; Jari O Laurikka; Sundararajan Srinivasan; Ify R Mordi; Stella Trompet; Adriaan Kraaijeveld; Jessica van Setten; Crystel M Gijsberts; Anke H Maitland-van der Zee; Christoph H Saely; Yan Gong; Julie A Johnson; Rhonda M Cooper-DeHoff; Carl J Pepine; Gavino Casu; Andreas Leiherer; Heinz Drexel; Benjamin D Horne; Sander W van der Laan; Nicola Marziliano; Stanley L Hazen; Juha Sinisalo; Mika Kähönen; Terho Lehtimäki; Chim C Lang; Ralph Burkhardt; Markus Scholz; J Wouter Jukema; Niclas Eriksson; Axel Åkerblom; Stefan James; Claes Held; Emil Hagström; John A Spertus; Ale Algra; Ulf de Faire; Agneta Åkesson; Folkert W Asselbergs; Riyaz S Patel; Karin Leander Journal: Front Physiol Date: 2022-06-23 Impact factor: 4.755