Literature DB >> 31252034

Glyburide, a NLRP3 Inhibitor, Decreases Inflammatory Response and Is a Candidate to Reduce Pathology in Leishmania braziliensis Infection.

Augusto M Carvalho1, Fernanda O Novais2, Camilla S Paixão3, Camila I de Oliveira3, Paulo Roberto Lima Machado4, Lucas P Carvalho4, Phillip Scott2, Edgar M Carvalho5.   

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Year:  2019        PMID： 31252034      PMCID： PMC7851844          DOI： 10.1016/j.jid.2019.05.025

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


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  15 in total

1.  Sensitivity of Leishmania spp. to glibenclamide and 4-aminopyridine: a tool for the study of drug resistance development.

Authors:  A Ponte-Sucre; Y Campos; J Vázquez; H Moll; A Mendoza-León
Journal:  Mem Inst Oswaldo Cruz       Date:  1997 Sep-Oct       Impact factor: 2.743

2.  Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.

Authors:  Xenón Serrano-Martín; Gilberto Payares; Alexis Mendoza-León
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

3.  IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

Authors:  Elena Voronov; Shahar Dotan; Lubov Gayvoronsky; Rosalyn M White; Idan Cohen; Yakov Krelin; Fabrice Benchetrit; Moshe Elkabets; Monika Huszar; Joseph El-On; Ron N Apte
Journal:  Int Immunol       Date:  2010-02-24       Impact factor: 4.823

Review 4.  Activation and regulation of the inflammasomes.

Authors:  Eicke Latz; T Sam Xiao; Andrea Stutz
Journal:  Nat Rev Immunol       Date:  2013-06       Impact factor: 53.106

5.  The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.

Authors:  Melanie Charmoy; Benjamin P Hurrell; Audrey Romano; Sang Hun Lee; Flavia Ribeiro-Gomes; Nicolas Riteau; Katrin Mayer-Barber; Fabienne Tacchini-Cottier; David L Sacks
Journal:  Eur J Immunol       Date:  2016-01-20       Impact factor: 5.532

6.  Immunologic response and memory T cells in subjects cured of tegumentary leishmaniasis.

Authors:  Augusto M Carvalho; Andréa Magalhães; Lucas P Carvalho; Olívia Bacellar; Phillip Scott; Edgar M Carvalho
Journal:  BMC Infect Dis       Date:  2013-11-09       Impact factor: 3.090

7.  CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.

Authors:  Fernanda O Novais; Augusto M Carvalho; Megan L Clark; Lucas P Carvalho; Daniel P Beiting; Igor E Brodsky; Edgar M Carvalho; Phillip Scott
Journal:  PLoS Pathog       Date:  2017-02-13       Impact factor: 6.823

8.  Protective and pathologic immune responses in human tegumentary leishmaniasis.

Authors:  Lucas P Carvalho; Sara Passos; Albert Schriefer; Edgar M Carvalho
Journal:  Front Immunol       Date:  2012-10-04       Impact factor: 7.561

9.  IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection.

Authors:  Claudia Gonzalez-Lombana; Ciara Gimblet; Olivia Bacellar; Walker W Oliveira; Sara Passos; Lucas P Carvalho; Michael Goldschmidt; Edgar M Carvalho; Phillip Scott
Journal:  PLoS Pathog       Date:  2013-03-21       Impact factor: 6.823

10.  The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis.

Authors:  Pedro Paulo Carneiro; Jacilara Conceição; Michael Macedo; Viviane Magalhães; Edgar M Carvalho; Olivia Bacellar
Journal:  PLoS One       Date:  2016-02-03       Impact factor: 3.240
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  13 in total

Review 1.  Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis.

Authors:  Valerie Harrington; Prajwal Gurung
Journal:  Immunol Rev       Date:  2020-06-20       Impact factor: 12.988

2.  Impaired Th1 Response Is Associated With Therapeutic Failure in Patients With Cutaneous Leishmaniasis Caused by Leishmania braziliensis.

Authors:  Augusto M Carvalho; Luiz H Guimarães; Rúbia Costa; Maíra G Saldanha; Iana Prates; Lucas P Carvalho; Sérgio Arruda; Edgar M Carvalho
Journal:  J Infect Dis       Date:  2021-02-13       Impact factor: 5.226

3.  Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8+ T cell immunosenescence signature linked to immunopathology.

Authors:  Carlos Henrique Fantecelle; Luciana Polaco Covre; Renan Garcia de Moura; Herbert Leonel de Matos Guedes; Camila Farias Amorim; Phillip Scott; David Mosser; Aloisio Falqueto; Arne N Akbar; Daniel Claudio Oliveira Gomes
Journal:  Immunology       Date:  2021-09-01       Impact factor: 7.397

4.  The level of interleukin-17, 23, and gamma interferon in cutaneous leishmaniasis patients before and after intra lesion treatment.

Authors:  Mehdi Ghazanfari; Bahador Shahriari; Vahid Rahnama; Meisam Khazaei; Shahrbanou Naderi; Mohammad Hossein Motazedian
Journal:  J Parasit Dis       Date:  2022-02-03

5.  PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis.

Authors:  Renan Garcia de Moura; Luciana Polaco Covre; Carlos Henrique Fantecelle; Vitor Alejandro Torres Gajardo; Carla Baroni Cunha; Lorenzzo Lyrio Stringari; Ashton Trey Belew; Camila Batista Daniel; Sandra Ventorin Von Zeidler; Carlos Eduardo Tadokoro; Herbert Leonel de Matos Guedes; Raphael Lubiana Zanotti; David Mosser; Aloisio Falqueto; Arne N Akbar; Daniel Claudio Oliveira Gomes
Journal:  Front Immunol       Date:  2021-03-09       Impact factor: 7.561

6.  Diabetes Modifies the Clinic Presentation of Cutaneous Leishmaniasis.

Authors:  Alexsandro S Lago; Filipe R Lima; Augusto M Carvalho; Camilla Sampaio; Neuza Lago; Luiz H Guimarães; Jamile Lago; Paulo R L Machado; Lucas P Carvalho; Sérgio Arruda; Edgar M Carvalho
Journal:  Open Forum Infect Dis       Date:  2020-10-19       Impact factor: 3.835

7.  Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation.

Authors:  Ning Cao; Jing-Jing Wang; Ji-Min Wu; Wen-Li Xu; Rui Wang; Xian-da Chen; Ye-Nan Feng; Wen-Wen Cong; You-Yi Zhang; Han Xiao; Er-Dan Dong
Journal:  Acta Pharmacol Sin       Date:  2021-08-04       Impact factor: 6.150

Review 8.  The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets.

Authors:  Rongrong Bai; Yue Lang; Jie Shao; Yu Deng; Reyisha Refuhati; Li Cui
Journal:  ASN Neuro       Date:  2021 Jan-Dec       Impact factor: 4.146

9.  Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis.

Authors:  Pedro Paulo Carneiro; Andreza S Dórea; Walker N Oliveira; Luiz Henrique Guimarães; Claúdia Brodskyn; Edgar M Carvalho; Olívia Bacellar
Journal:  Front Immunol       Date:  2021-10-06       Impact factor: 7.561

10.  Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis.

Authors:  Maurício T Nascimento; Mônica Franca; Augusto M Carvalho; Camila F Amorim; Fábio Peixoto; Daniel Beiting; Phillip Scott; Edgar M Carvalho; Lucas P Carvalho
Journal:  Emerg Microbes Infect       Date:  2021-12       Impact factor: 7.163
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