Literature DB >> 3124840

Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.

S Lavu1, J Clark, R Swarup, K Matsushima, K Paturu, J Moss, H F Kung.   

Abstract

The nucleotide sequence of human Go alpha was determined from a partial human brain cDNA clone and the sequence of the first two 5' coding exons of a human genomic Go alpha clone. Comparison of this sequence with bovine and rat Go alpha shows greater than 90% homology at the nucleotide and deduced amino acid level. There is 100% identity at the amino acid level for the cholera and pertussis toxin-catalyzed ADP ribosylation sites, the putative guanine nucleotide binding, and the GTP hydrolysis sites.

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Year:  1988        PMID： 3124840     DOI： 10.1016/0006-291x(88)90463-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type.

Authors:  Inaki Azpiazu; Muslum Akgoz; Vani Kalyanaraman; N Gautam
Journal:  Cell Signal       Date:  2005-10-19       Impact factor: 4.315

2.  Structure and function of the alpha-subunit of the GTP-binding protein Go from bovine cerebellum.

Authors:  V Z Slepak; A N Pronin; O G Kiselyov; V L Voeikov; E I Frolova; V M Lipkin
Journal:  J Protein Chem       Date:  1989-06

3.  Alternative splicing of the guanine nucleotide-binding regulatory protein Go alpha generates four distinct mRNAs.

Authors:  J J Murtagh; J Moss; M Vaughan
Journal:  Nucleic Acids Res       Date:  1994-03-11       Impact factor: 16.971

4.  Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity.

Authors:  Y M Hajdu-Cronin; W J Chen; G Patikoglou; M R Koelle; P W Sternberg
Journal:  Genes Dev       Date:  1999-07-15       Impact factor: 11.361

5.  Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16.

Authors:  J J Murtagh; R Eddy; T B Shows; J Moss; M Vaughan
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

6.  Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

Authors:  T Tsukamoto; R Toyama; H Itoh; T Kozasa; M Matsuoka; Y Kaziro
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

7.  The molecular cloning of the squid (Loligo forbesi) visual Gq-alpha subunit and its expression in Saccharomyces cerevisiae.

Authors:  N J Ryba; J B Findlay; J D Reid
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857

8.  High expression of TAZ indicates a poor prognosis in retinoblastoma.

Authors:  Yiting Zhang; Chunyan Xue; Hongjuan Cui; Zhenping Huang
Journal:  Diagn Pathol       Date:  2015-10-13       Impact factor: 2.644

Review 9.  Pathomechanisms in schwannoma development and progression.

Authors:  Dario-Lucas Helbing; Alexander Schulz; Helen Morrison
Journal:  Oncogene       Date:  2020-07-02       Impact factor: 9.867

10.  Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts.

Authors:  Benjamin Wasinski; Anjum Sohail; R Daniel Bonfil; Seongho Kim; Allen Saliganan; Lisa Polin; Mohamad Bouhamdan; Hyeong-Reh C Kim; Marco Prunotto; Rafael Fridman
Journal:  Sci Rep       Date:  2020-02-11       Impact factor: 4.379
  10 in total

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