Literature DB >> 8503868

The molecular cloning of the squid (Loligo forbesi) visual Gq-alpha subunit and its expression in Saccharomyces cerevisiae.

N J Ryba1, J B Findlay, J D Reid.   

Abstract

The sequence of the alpha-subunit of the major G-protein from the squid (Loligo forbesi) retina was predicted from its cDNA to be a member of the Gq subclass. The abundance of the squid Gq-alpha in the squid photoreceptor membranes suggests that the protein functions in phototransduction; the sequence of this G-protein is consistent with it mediating the light-dependent activation of a phospholipase C. The squid G-alpha was expressed in the yeast Saccharomyces cerevisiae, where it was unable to replace the function of GPA1, the yeast G-alpha homologue that regulates the mating response, suggesting that Gq-alpha was unable to interact with the endogenous G-beta gamma (STE4-STE18).

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Year:  1993        PMID： 8503868      PMCID： PMC1134214          DOI： 10.1042/bj2920333

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  44 in total

1.  Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

Authors:  T L Jones; W F Simonds; J J Merendino; M R Brann; A M Spiegel
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

2.  Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence.

Authors:  D C Medynski; K Sullivan; D Smith; C Van Dop; F H Chang; B K Fung; P H Seeburg; H R Bourne
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

3.  Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase.

Authors:  R Mattera; J Codina; A Crozat; V Kidd; S L Woo; L Birnbaumer
Journal:  FEBS Lett       Date:  1986-09-29       Impact factor: 4.124

4.  Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway.

Authors:  Y S Kang; J Kane; J Kurjan; J M Stadel; D J Tipper
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

5.  Squid rhodopsin and GTP-binding protein crossreact with vertebrate photoreceptor enzymes.

Authors:  H R Saibil; M Michel-Villaz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

6.  Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.

Authors:  S J Taylor; J A Smith; J H Exton
Journal:  J Biol Chem       Date:  1990-10-05       Impact factor: 5.157

7.  Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA.

Authors:  J R Didsbury; Y S Ho; R Snyderman
Journal:  FEBS Lett       Date:  1987-01-26       Impact factor: 4.124

8.  Light stimulates the rapid formation of inositol trisphosphate in squid retinas.

Authors:  E Z Szuts; S F Wood; M S Reid; A Fein
Journal:  Biochem J       Date:  1986-12-15       Impact factor: 3.857

9.  Solubilization of active somatostatin receptors from rat brain.

Authors:  H T He; S Rens-Domiano; J M Martin; S F Law; S Borislow; M Woolkalis; D Manning; T Reisine
Journal:  Mol Pharmacol       Date:  1990-05       Impact factor: 4.436

10.  Regulation of the yeast pheromone response pathway by G protein subunits.

Authors:  S Nomoto; N Nakayama; K Arai; K Matsumoto
Journal:  EMBO J       Date:  1990-03       Impact factor: 11.598
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  5 in total

Review 1.  The ordered visual transduction complex of the squid photoreceptor membrane.

Authors:  J S Lott; J I Wilde; A Carne; N Evans; J B Findlay
Journal:  Mol Neurobiol       Date:  1999-08       Impact factor: 5.590

2.  Molecular and immunological characterization of a Gq protein from ventral and lateral eye of the horseshoe crab Limulus polyphemus.

Authors:  S D Munger; J L Schremser-Berlin; C M Brink; B A Battelle
Journal:  Invert Neurosci       Date:  1996-12

3.  Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker.

Authors:  C E Alvarez; K Robison; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

4.  Protein-protein interactions in the yeast PKC1 pathway: Pkc1p interacts with a component of the MAP kinase cascade.

Authors:  G Paravicini; L Friedli
Journal:  Mol Gen Genet       Date:  1996-07-26

5.  Xenopus Gq alpha subunit activates the phosphatidylinositol pathway in Xenopus oocytes but does not consistently induce oocyte maturation.

Authors:  K L Guttridge; L D Smith; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205
  5 in total

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