Literature DB >> 31246040

Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.

Wei-Hua Jiao1, Jing Li1,2, Meng-Meng Zhang3, Jie Cui1, Yu-Han Gui1, Yun Zhang4, Jing-Ya Li3, Ke-Chun Liu4, Hou-Wen Lin1.   

Abstract

The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.

Entities:  

Year:  2019        PMID： 31246040     DOI： 10.1021/acs.orglett.9b01754

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  Peculiarities of meroterpenoids and their bioproduction.

Authors:  Jianying Han; Lan Jiang; Lixin Zhang; Ronald J Quinn; Xueting Liu; Yunjiang Feng
Journal:  Appl Microbiol Biotechnol       Date:  2021-05-03       Impact factor: 4.813

2.  Cytotoxic Psammaplysin Analogues from the Verongid Red Sea Sponge Aplysinella Species.

Authors:  Lamiaa A Shaala; Diaa T A Youssef
Journal:  Biomolecules       Date:  2019-12-08

3.  Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3-Bis(aminomethylene)succinamide Backbone from the Red Sea Sponge Pseudoceratina arabica.

Authors:  Diaa T A Youssef; Hani Z Asfour; Lamiaa A Shaala
Journal:  Mar Drugs       Date:  2021-07-29       Impact factor: 5.118

Review 4.  Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis.

Authors:  Paulo E S Munekata; Mirian Pateiro; Carlos A Conte-Junior; Rubén Domínguez; Asad Nawaz; Noman Walayat; Elena Movilla Fierro; José M Lorenzo
Journal:  Mar Drugs       Date:  2021-06-28       Impact factor: 5.118

5.  Structure Revision and Protein Tyrosine Phosphatase Inhibitory Activity of Drazepinone.

Authors:  Fei Cao; Li Pan; Wenbin Gao; Yunfeng Liu; Caijuan Zheng; Yahui Zhang
Journal:  Mar Drugs       Date:  2021-12-20       Impact factor: 5.118

6.  Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus Aspergillus sp. 16-5c.

Authors:  Geting Ye; Cuiying Huang; Jialin Li; Tao Chen; Jing Tang; Wenbin Liu; Yuhua Long
Journal:  Mar Drugs       Date:  2021-07-20       Impact factor: 5.118
  6 in total

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