PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation. RECENT FINDINGS: Heart transplantation is now an established therapy for end-stage heart failure, though challenges still exist. However, multiple advances over the past few years will improve the survival and quality of life of heart transplant recipients. These advances include acceptance of previously considered marginal donor hearts, revisions to the donor heart allocation policy, advances in desensitization regimens, tailoring of immunosuppression regimens, and improvement in the diagnosis of rejection and allograft vasculopathy. Heart transplantation is evolving to provide better quality of life and survival to higher risk recipients with methods to broaden the donor pool, make the best use of existing organs, and refine the management of sensitization and diagnosis of rejection and allograft vasculopathy.
PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation. RECENT FINDINGS: Heart transplantation is now an established therapy for end-stage heart failure, though challenges still exist. However, multiple advances over the past few years will improve the survival and quality of life of heart transplant recipients. These advances include acceptance of previously considered marginal donor hearts, revisions to the donor heart allocation policy, advances in desensitization regimens, tailoring of immunosuppression regimens, and improvement in the diagnosis of rejection and allograft vasculopathy. Heart transplantation is evolving to provide better quality of life and survival to higher risk recipients with methods to broaden the donor pool, make the best use of existing organs, and refine the management of sensitization and diagnosis of rejection and allograft vasculopathy.
Authors: Omar Wever-Pinzon; Jorge Romero; Iosif Kelesidis; James Wever-Pinzon; Carlos Manrique; Deborah Budge; Stavros G Drakos; Ileana L Piña; Abdallah G Kfoury; Mario J Garcia; Josef Stehlik Journal: J Am Coll Cardiol Date: 2014-03-26 Impact factor: 24.094
Authors: Philip F Halloran; Jeff P Reeve; Andre B Pereira; Luis G Hidalgo; Konrad S Famulski Journal: Kidney Int Date: 2013-08-21 Impact factor: 10.612
Authors: Lars H Lund; Kiran K Khush; Wida S Cherikh; Samuel Goldfarb; Anna Y Kucheryavaya; Bronwyn J Levvey; Bruno Meiser; Joseph W Rossano; Daniel C Chambers; Roger D Yusen; Josef Stehlik Journal: J Heart Lung Transplant Date: 2017-07-20 Impact factor: 10.247
Authors: Josef Stehlik; Jon Kobashigawa; Sharon A Hunt; Hermann Reichenspurner; James K Kirklin Journal: Circulation Date: 2018-01-02 Impact factor: 29.690
Authors: J A Kobashigawa; M Johnson; J Rogers; J D Vega; M Colvin-Adams; L Edwards; D Meyer; M Luu; N Reinsmoen; A I Dipchand; D Feldman; R Kormos; D Mancini; S Webber Journal: Am J Transplant Date: 2015-01 Impact factor: 8.086
Authors: J Kobashigawa; K Khush; M Colvin; M Acker; A Van Bakel; H Eisen; Y Naka; J Patel; D A Baran; T Daun; M Luu; M Olymbios; J Rogers; V Jeevanandam; F Esmailian; F D Pagani; B Lima; J Stehlik Journal: Am J Transplant Date: 2017-06-13 Impact factor: 8.086
Authors: D Sawinski; N Kaur; A Ajeti; J Trofe-Clark; M Lim; M Bleicher; S Goral; K A Forde; R D Bloom Journal: Am J Transplant Date: 2016-02-05 Impact factor: 8.086