Literature DB >> 31237484

Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage Repair In Vitro.

Paul H Liebesny1, Keri Mroszczyk2, Hannah Zlotnick1, Han-Hwa Hung1, Eliot Frank1, Bodo Kurz3, Gustavo Zanotto4, David Frisbie4, Alan J Grodzinsky1,2,5.   

Abstract

IMPACT STATEMENT: A critical attribute for the long-term success of cartilage defect repair is the strong integration between the repair tissue and the surrounding native tissue. Current approaches utilized by physicians fail to achieve this attribute, leading to eventual relapse of the defect. This article demonstrates the concept of a simple, clinically viable approach for enhancing tissue integration via the combination of a safe, transient enzymatic treatment with a locally delivered, retained growth factor through an in vitro hydrogel/cartilage explant model.

Entities:  

Keywords:  HB-IGF-1; cartilage repair; scaffolds; trypsin

Mesh：

Substances：

Year:  2019        PMID： 31237484      PMCID： PMC6760182          DOI： 10.1089/ten.TEA.2019.0013

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  57 in total

1.  Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system.

Authors:  P M Ragan; V I Chin; H H Hung; K Masuda; E J Thonar; E C Arner; A J Grodzinsky; J D Sandy
Journal:  Arch Biochem Biophys       Date:  2000-11-15       Impact factor: 4.013

2.  Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach.

Authors:  Matthew B Fisher; Elizabeth A Henning; Nicole B Söegaard; George R Dodge; David R Steinberg; Robert L Mauck
Journal:  Biomaterials       Date:  2013-12-04       Impact factor: 12.479

Review 3.  Articular cartilage and osteoarthritis.

Authors:  Joseph A Buckwalter; Henry J Mankin; Alan J Grodzinsky
Journal:  Instr Course Lect       Date:  2005

4.  Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model.

Authors:  Rachel E Miller; Alan J Grodzinsky; Myra F Barrett; Han-Hwa Hung; Eliot H Frank; Natasha M Werpy; C Wayne McIlwraith; David D Frisbie
Journal:  J Bone Joint Surg Am       Date:  2014-10-01       Impact factor: 5.284

5.  Integration of engineered cartilage.

Authors:  B Obradovic; I Martin; R F Padera; S Treppo; L E Freed; G Vunjak-Novakovic
Journal:  J Orthop Res       Date:  2001-11       Impact factor: 3.494

6.  Controlled enzymatic matrix degradation for integrative cartilage repair: effects on viable cell density and proteoglycan deposition.

Authors:  Thomas M Quinn; Ernst B Hunziker
Journal:  Tissue Eng       Date:  2002-10

7.  Tracking chondrocytes and assessing their proliferation with PKH26: effects on secretion of proteoglycan 4 (PRG4).

Authors:  Kanika Chawla; Travis J Klein; Barbara L Schumacher; Tannin A Schmidt; Michael S Voegtline; Eugene J-M A Thonar; Koichi Masuda; Robert L Sah
Journal:  J Orthop Res       Date:  2006-07       Impact factor: 3.494

8.  Novel scaffold-based BST-CarGel treatment results in superior cartilage repair compared with microfracture in a randomized controlled trial.

Authors:  William D Stanish; Robert McCormack; Francisco Forriol; Nicholas Mohtadi; Stéphane Pelet; Jacques Desnoyers; Alberto Restrepo; Matthew S Shive
Journal:  J Bone Joint Surg Am       Date:  2013-09-18       Impact factor: 5.284

9.  Effect of matrix depleting agents on the expression of chondrocyte metabolism by equine chondrocytes.

Authors:  J Iqbal; J L Bird; A P Hollander; M T Bayliss
Journal:  Res Vet Sci       Date:  2004-12       Impact factor: 2.534

10.  Identification and characterization of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases in human synovial fluid.

Authors:  T Matsumoto; S E Gargosky; K Iwasaki; R G Rosenfeld
Journal:  J Clin Endocrinol Metab       Date:  1996-01       Impact factor: 5.958
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  7 in total

1.  Trypsin Pre-Treatment Combined With Growth Factor Functionalized Self-Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model.

Authors:  Gustavo Zanotto; Paul Liebesny; Myra Barrett; Hannah Zlotnick; Alan Grodzinsky; David Frisbie
Journal:  J Orthop Res       Date:  2019-08-06       Impact factor: 3.494

2.  Fabrication of MSC-laden composites of hyaluronic acid hydrogels reinforced with MEW scaffolds for cartilage repair.

Authors:  Jonathan H Galarraga; Ryan C Locke; Claire E Witherel; Brendan D Stoeckl; Miguel Castilho; Robert L Mauck; Jos Malda; Riccardo Levato; Jason A Burdick
Journal:  Biofabrication       Date:  2021-12-01       Impact factor: 9.954

Review 3.  Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review.

Authors:  Qian Zhang; Yixin Hu; Xuan Long; Lingling Hu; Yu Wu; Ji Wu; Xiaobing Shi; Runqi Xie; Yu Bi; Fangyuan Yu; Pinxue Li; Yu Yang
Journal:  Front Bioeng Biotechnol       Date:  2022-06-30

4.  Chondroitinase ABC Enhances Integration of Self-Assembled Articular Cartilage, but Its Dosage Needs to Be Moderated Based on Neocartilage Maturity.

Authors:  Jarrett M Link; Jerry C Hu; Kyriacos A Athanasiou
Journal:  Cartilage       Date:  2020-05-22       Impact factor: 3.117

5.  Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent.

Authors:  Md Shafiullah Shajib; Kathryn Futrega; Travis Jacob Klein; Ross W Crawford; Michael Robert Doran
Journal:  J Tissue Eng       Date:  2022-01-23       Impact factor: 7.813

6.  Impediments to Meniscal Repair: Factors at Play Beyond Vascularity.

Authors:  Jay M Patel
Journal:  Front Bioeng Biotechnol       Date:  2022-03-01

Review 7.  New Insights into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration.

Authors:  Sahar Jelodari; Amin Ebrahimi Sadrabadi; Fatemeh Zarei; Shahrbanoo Jahangir; Mahmoud Azami; Mohsen Sheykhhasan; Samaneh Hosseini
Journal:  Biomed Res Int       Date:  2022-01-25       Impact factor: 3.411
  7 in total

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