Victoria M Leavitt1,2, Rachel Brandstadter3, Michelle Fabian3, Ilana Katz Sand3, Sylvia Klineova3, Stephen Krieger3, Christina Lewis3, Fred Lublin3, Aaron Miller3, Gabrielle Pelle3, Korhan Buyukturkoglu1, Phillip L De Jager4, Peipei Li1, Claire S Riley5, Angeliki Tsapanou5, James F Sumowski3. 1. Translational Cognitive Neuroscience Laboratory, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA/Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. 2. Translational Cognitive Neuroscience Laboratory, Department of Neurology, Columbia University Irving Medical Center, 630 West 168th Street, P&S Box 16, New York, NY 10032, USA. 3. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai Hospital, New York, NY, USA. 4. Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA/Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. 5. Multiple Sclerosis Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Abstract
BACKGROUND: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. OBJECTIVE: To identify cognitive functions associated with anxiety and depression in MS. METHODS: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. RESULTS: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = -0.220, p = 0.003) and lower depression to better attention/processing speed (rp = -0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = -0.271, p = 0.028) and lower depression to better attention/processing speed (rp = -0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. CONCLUSION: Consistent mood-cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
BACKGROUND: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. OBJECTIVE: To identify cognitive functions associated with anxiety and depression in MS. METHODS: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. RESULTS: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = -0.220, p = 0.003) and lower depression to better attention/processing speed (rp = -0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = -0.271, p = 0.028) and lower depression to better attention/processing speed (rp = -0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. CONCLUSION: Consistent mood-cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
Authors: Maria A Rocca; Maria P Amato; Nicola De Stefano; Christian Enzinger; Jeroen J Geurts; Iris-K Penner; Alex Rovira; James F Sumowski; Paola Valsasina; Massimo Filippi Journal: Lancet Neurol Date: 2015-02-04 Impact factor: 44.182
Authors: Korhan Buyukturkoglu; Christopher Vergara; Valentina Fuentealba; Ceren Tozlu; Jacob B Dahan; Britta E Carroll; Amy Kuceyeski; Claire S Riley; James F Sumowski; Carlos Guevara Oliva; Ranganatha Sitaram; Pamela Guevara; Victoria M Leavitt Journal: J Neuroimaging Date: 2021-09-17 Impact factor: 2.486
Authors: Ruth Ann Marrie; Ronak Patel; Chase R Figley; Jennifer Kornelsen; James M Bolton; Lesley A Graff; Erin L Mazerolle; Carl Helmick; Md Nasir Uddin; Teresa D Figley; James J Marriott; Charles N Bernstein; John D Fisk Journal: Front Neurol Date: 2022-05-24 Impact factor: 4.086
Authors: Sinah Engel; Christiane Graetz; Anke Salmen; Muthuraman Muthuraman; Gerrit Toenges; Björn Ambrosius; Antonios Bayas; Achim Berthele; Christoph Heesen; Luisa Klotz; Tania Kümpfel; Ralf A Linker; Sven G Meuth; Friedemann Paul; Martin Stangel; Björn Tackenberg; Florian Then Bergh; Hayrettin Tumani; Frank Weber; Brigitte Wildemann; Uwe K Zettl; Gisela Antony; Stefan Bittner; Sergiu Groppa; Bernhard Hemmer; Heinz Wiendl; Ralf Gold; Frauke Zipp; Christina M Lill; Felix Luessi Journal: Neurol Neuroimmunol Neuroinflamm Date: 2020-05-01
Authors: Rocío Benítez-Fernández; Carolina Melero-Jerez; Carmen Gil; Enrique J de la Rosa; Ana Martínez; Fernando de Castro Journal: Int J Mol Sci Date: 2021-02-28 Impact factor: 5.923