Literature DB >> 31211230

Insights into mitotic checkpoint by integrating CRISPR and RNAi.

Gang Zhang1,2,3.   

Abstract

Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity. This rings alarm bells on the application of CRISPR technology.

Entities:  

Keywords:  BUB1; CRISPR; ROD; Spindle assembly checkpoint

Year:  2019        PMID： 31211230      PMCID： PMC6548497          DOI： 10.1080/23723556.2019.1603436

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

Authors:  Victoria L Johnson; Maria I F Scott; Sarah V Holt; Deema Hussein; Stephen S Taylor
Journal:  J Cell Sci       Date:  2004-03-15       Impact factor: 5.285

2.  S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.

Authors:  M A Hoyt; L Totis; B T Roberts
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

3.  Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells.

Authors:  Cerys E Currie; Mar Mora-Santos; Chris A Smith; Andrew D McAinsh; Jonathan B A Millar
Journal:  Curr Biol       Date:  2018-09-10       Impact factor: 10.834

4.  BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Authors:  Jonne A Raaijmakers; Roy G H P van Heesbeen; Vincent A Blomen; Louise M E Janssen; Ferdy van Diemen; Thijn R Brummelkamp; René H Medema
Journal:  Cell Rep       Date:  2018-02-06       Impact factor: 9.423

5.  Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion.

Authors:  Jose-Antonio Rodriguez-Rodriguez; Clare Lewis; Kara L McKinley; Vitali Sikirzhytski; Jennifer Corona; John Maciejowski; Alexey Khodjakov; Iain M Cheeseman; Prasad V Jallepalli
Journal:  Curr Biol       Date:  2018-10-25       Impact factor: 10.834

6.  A dual role for Bub1 in the spindle checkpoint and chromosome congression.

Authors:  Patrick Meraldi; Peter K Sorger
Journal:  EMBO J       Date:  2005-03-31       Impact factor: 11.598

7.  Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex.

Authors:  Gang Zhang; Thomas Kruse; Claudia Guasch Boldú; Dimitriya H Garvanska; Fabian Coscia; Matthias Mann; Marin Barisic; Jakob Nilsson
Journal:  EMBO J       Date:  2019-02-19       Impact factor: 11.598

8.  The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity.

Authors:  Thomas Wild; Marie Sofie Yoo Larsen; Takeo Narita; Julie Schou; Jakob Nilsson; Chunaram Choudhary
Journal:  Cell Rep       Date:  2016-02-18       Impact factor: 9.423

9.  Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling.

Authors:  Gang Zhang; Thomas Kruse; Blanca López-Méndez; Kathrine Beck Sylvestersen; Dimitriya H Garvanska; Simone Schopper; Michael Lund Nielsen; Jakob Nilsson
Journal:  Nat Commun       Date:  2017-06-12       Impact factor: 14.919
  9 in total

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