K Chen1, J Quan2, J Yang3, Z Chen4. 1. Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, No. 158 Shangtang Road, Hangzhou, 310000, Zhejiang, People's Republic of China. 2. Department of Oncology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi, People's Republic of China. 3. Department of Medical Oncology, First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road of Xi'an, Xi'an, 710000, People's Republic of China. 4. Department of Medical Oncology, Zhejiang Province People's Hospital, No. 158 Shangtang Road, Hangzhou, 310000, Zhejiang, People's Republic of China. 383974903@qq.com.
Abstract
PURPOSE: Breast cancer with positive hormone receptor (HR) and human epidermal growth factor receptor-2 (HER2) is a special subgroup with different clinical features and survival, especially the endocrine therapy resistance. The main purpose of the study is to find the potential markers to predict the survival and endocrine therapy resistance of patients with HR+ /HER2+ breast cancer. METHODS: Surveillance, Epidemiology, and End Results (SEER) database was used to collect patients' clinical information and tumor features including age, tumor size, grade, stage and long-term survival; the BioPortal for Cancer Genomics (https://cbioportal.org) was used to download the gene data for specific patient group; cluster analyses of gene expression were conducted through the DAVID Bioinformatics Resources 6.8 software. RESULTS: All of the included patients were diagnosed as HR positive breast cancer, but the PR positive rates were more common in HER2- group and also the ER+ /PR+ disease. Patients in HR+ /HER2+ group were more likely to present as stage III-IV and grade III disease. Among HR+ /HER2+ patients, 68.6% received chemotherapy, while only 28.9% in HR+ /HER2- group received chemotherapy (P < 0.0001). The survival of HR+ /HER2+ group was poorer. From TCGA database, series genes which were differed between HR+ /HER2+ and HR+ /HER2- were screened out that related to ERBB2 closely: IKZF3, LASP1, CDK12, MLLT6, and RARA. The first three candidate genes were associated with patients' survival, especially in patients who received hormone therapies. CONCLUSION: This study analyzed the clinical characteristics and survival of patients with HR+/HER2+ breast cancer as a special subgroup. ERBB2, IKZF3, LASP1, and CDK12 were the potential markers of the resistance of endocrine therapy, and they will provide new strategies for clinicians.
PURPOSE:Breast cancer with positive hormone receptor (HR) and humanepidermal growth factor receptor-2 (HER2) is a special subgroup with different clinical features and survival, especially the endocrine therapy resistance. The main purpose of the study is to find the potential markers to predict the survival and endocrine therapy resistance of patients with HR+ /HER2+ breast cancer. METHODS: Surveillance, Epidemiology, and End Results (SEER) database was used to collect patients' clinical information and tumor features including age, tumor size, grade, stage and long-term survival; the BioPortal for Cancer Genomics (https://cbioportal.org) was used to download the gene data for specific patient group; cluster analyses of gene expression were conducted through the DAVID Bioinformatics Resources 6.8 software. RESULTS: All of the included patients were diagnosed as HR positive breast cancer, but the PR positive rates were more common in HER2- group and also the ER+ /PR+ disease. Patients in HR+ /HER2+ group were more likely to present as stage III-IV and grade III disease. Among HR+ /HER2+ patients, 68.6% received chemotherapy, while only 28.9% in HR+ /HER2- group received chemotherapy (P < 0.0001). The survival of HR+ /HER2+ group was poorer. From TCGA database, series genes which were differed between HR+ /HER2+ and HR+ /HER2- were screened out that related to ERBB2 closely: IKZF3, LASP1, CDK12, MLLT6, and RARA. The first three candidate genes were associated with patients' survival, especially in patients who received hormone therapies. CONCLUSION: This study analyzed the clinical characteristics and survival of patients with HR+/HER2+ breast cancer as a special subgroup. ERBB2, IKZF3, LASP1, and CDK12 were the potential markers of the resistance of endocrine therapy, and they will provide new strategies for clinicians.
Authors: P Kelly Marcom; Claudine Isaacs; Lyndsay Harris; Zee Wang Wong; Aruna Kommarreddy; Nellie Novielli; Gretchen Mann; Yu Tao; Matthew J Ellis Journal: Breast Cancer Res Treat Date: 2006-08-08 Impact factor: 4.872
Authors: Birgitte B Rasmussen; Meredith M Regan; Anne E Lykkesfeldt; Patrizia Dell'Orto; Barbara Del Curto; Katrine L Henriksen; Mauro G Mastropasqua; Karen N Price; Eliane Méry; Magali Lacroix-Triki; Stephen Braye; Hans J Altermatt; Richard D Gelber; Monica Castiglione-Gertsch; Aron Goldhirsch; Barry A Gusterson; Beat Thürlimann; Alan S Coates; Giuseppe Viale Journal: Lancet Oncol Date: 2007-12-20 Impact factor: 41.316
Authors: Naoise C Synnott; Matthias R Bauer; Stephen Madden; Alyson Murray; Rut Klinger; Norma O'Donovan; Darran O'Connor; William M Gallagher; John Crown; Alan R Fersht; Michael J Duffy Journal: Cancer Lett Date: 2017-10-22 Impact factor: 8.679
Authors: Shemra Rizzo; Sarah Waliany; Marius Rene Garmhausen; Navdeep Pal; Ruishan Liu; Zhi Huang; Nayan Chaudhary; Lisa Wang; Chris Harbron; Joel Neal; Ryan Copping; James Zou Journal: Nat Med Date: 2022-06-30 Impact factor: 87.241