| Literature DB >> 31209334 |
Erika von Mutius1,2,3, Juha Pekkanen4,5, Pirkka V Kirjavainen6,7, Anne M Karvonen4, Rachel I Adams8, Martin Täubel4, Marjut Roponen9, Pauli Tuoresmäki4,5, Georg Loss10, Balamuralikrishna Jayaprakash4, Martin Depner1, Markus Johannes Ege2,3, Harald Renz11, Petra Ina Pfefferle12, Bianca Schaub2,3, Roger Lauener13,14,15,16, Anne Hyvärinen4, Rob Knight17, Dick J J Heederik18.
Abstract
Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today1. The asthma-protective effect of farms appears to be associated with rich home dust microbiota2,3, which could be used to model a health-promoting indoor microbiome. Here we show by modeling differences in house dust microbiota composition between farm and non-farm homes of Finnish birth cohorts4 that in children who grow up in non-farm homes, asthma risk decreases as the similarity of their home bacterial microbiota composition to that of farm homes increases. The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-associated bacterial taxa. The protective effect was independent of richness and total bacterial load and was associated with reduced proinflammatory cytokine responses against bacterial cell wall components ex vivo. We were able to reproduce these findings in a study among rural German children2 and showed that children living in German non-farm homes with an indoor microbiota more similar to Finnish farm homes have decreased asthma risk. The indoor dust microbiota composition appears to be a definable, reproducible predictor of asthma risk and a potential modifiable target for asthma prevention.Entities:
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Year: 2019 PMID： 31209334 DOI： 10.1038/s41591-019-0469-4
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440