Literature DB >> 31209010

Loss of mcr Genes Mediated by Plasmid Elimination and ISApl1.

Pei Zhang1,2, Li Bai2, Yan Li3, Zhiqiang Wang3, Ruichao Li4,5.   

Abstract

We characterized the stability of a plasmid pCP53-mcr1_3 encoding mcr-1 and mcr-3.19 with and without colistin exposure during cultural passages via S1-pulsed-field gel electrophoresis (PFGE) and nanopore MinION sequencing. Both mcr-1 and mcr-3.19 were missing in certain subclones, mediated by genetic excision (ISApl1-mcr-1-pap2), and deletions of large multidrug resistance (MDR) regions confirmed by ISApl1 and plasmid elimination. Without colistin exposure, the eradication of mcr genes is feasible, while the factors influencing the elimination processes warrant further study.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  mcr genes; nanopore sequencing; plasmids

Mesh：

Substances：

Year:  2019        PMID： 31209010      PMCID： PMC6709468          DOI： 10.1128/AAC.01002-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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Authors:  Erik Snesrud; Susu He; Michael Chandler; John P Dekker; Alison B Hickman; Patrick McGann; Fred Dyda
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Journal:  J Antimicrob Chemother       Date:  2019-06-01       Impact factor: 5.790

7.  Analysis of Serial Isolates of mcr-1-Positive Escherichia coli Reveals a Highly Active ISApl1 Transposon.

Authors:  Erik Snesrud; Ana C Ong; Brendan Corey; Yoon I Kwak; Robert Clifford; Todd Gleeson; Shannon Wood; Timothy J Whitman; Emil P Lesho; Mary Hinkle; Patrick McGann
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