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Literature DB >> 31208695

Macropinocytosis in Cancer: A Complex Signaling Network.

Abstract

Macropinocytosis is an important nutrient-scavenging pathway in numerous cancer types, including pancreatic, lung, prostate, and bladder. This Forum highlights recent work identifying the key regulators of macropinocytosis that support tumor cell fitness in different contexts, providing a unique framework for strategies to target macropinocytosis in the treatment of cancer.

Entities: Chemical Disease Gene Species

Keywords: AMPK; PTEN; Ras; Wnt; integrin αvβ3; macropinocytosis; metabolism

Mesh：

Substances：
Biomarkers, Tumor

Year: 2019 PMID： 31208695 PMCID： PMC7325493 DOI： 10.1016/j.trecan.2019.04.002

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

14 in total

1. Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.

Authors: M Amyere; B Payrastre; U Krause; P Van Der Smissen; A Veithen; P J Courtoy
Journal: Mol Biol Cell Date: 2000-10 Impact factor: 4.138

Review 2. Defining macropinocytosis.

Authors: Markus C Kerr; Rohan D Teasdale
Journal: Traffic Date: 2009-01-24 Impact factor: 6.215

3. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins.

Authors: D Bar-Sagi; J R Feramisco
Journal: Science Date: 1986-09-05 Impact factor: 47.728

4. PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Authors: Seong M Kim; Tricia T Nguyen; Archna Ravi; Peter Kubiniok; Brendan T Finicle; Vaishali Jayashankar; Leonel Malacrida; Jue Hou; Jane Robertson; Dong Gao; Jonathan Chernoff; Michelle A Digman; Eric O Potma; Bruce J Tromberg; Pierre Thibault; Aimee L Edinger
Journal: Cancer Discov Date: 2018-03-23 Impact factor: 39.397

Review 5. RAS isoforms and mutations in cancer at a glance.

Authors: G Aaron Hobbs; Channing J Der; Kent L Rossman
Journal: J Cell Sci Date: 2016-03-16 Impact factor: 5.285

6. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers.

Authors: Laetitia Seguin; Maria F Camargo; Hiromi I Wettersten; Shumei Kato; Jay S Desgrosellier; Tami von Schalscha; Kathryn C Elliott; Erika Cosset; Jacqueline Lesperance; Sara M Weis; David A Cheresh
Journal: Cancer Discov Date: 2017-09-11 Impact factor: 39.397

Review 7. Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation.

Authors: Youhei Egami; Tomohiko Taguchi; Masashi Maekawa; Hiroyuki Arai; Nobukazu Araki
Journal: Front Physiol Date: 2014-09-30 Impact factor: 4.566

Review 8. Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.

Authors: Maria Victoria Recouvreux; Cosimo Commisso
Journal: Front Endocrinol (Lausanne) Date: 2017-09-29 Impact factor: 5.555

9. v-Src induces constitutive macropinocytosis in rat fibroblasts.

Authors: A Veithen; P Cupers; P Baudhuin; P J Courtoy
Journal: J Cell Sci Date: 1996-08 Impact factor: 5.285

10. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Authors: Cosimo Commisso; Shawn M Davidson; Rengin G Soydaner-Azeloglu; Seth J Parker; Jurre J Kamphorst; Sean Hackett; Elda Grabocka; Michel Nofal; Jeffrey A Drebin; Craig B Thompson; Joshua D Rabinowitz; Christian M Metallo; Matthew G Vander Heiden; Dafna Bar-Sagi
Journal: Nature Date: 2013-05-12 Impact factor: 49.962

22 in total

Review 10. Cancer metabolism: looking forward.

Authors: Inmaculada Martínez-Reyes; Navdeep S Chandel
Journal: Nat Rev Cancer Date: 2021-07-16 Impact factor: 60.716

Macropinocytosis in Cancer: A Complex Signaling Network.

1. Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.

Review 2. Defining macropinocytosis.

3. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins.

4. PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Review 5. RAS isoforms and mutations in cancer at a glance.

6. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers.

Review 7. Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation.

Review 8. Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.

9. v-Src induces constitutive macropinocytosis in rat fibroblasts.

10. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

1. Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes.

2. Signaling Pathways that Regulate Macropinocytosis in Mammalian Cells.

3. Rac1 and EGFR cooperate to activate Pak in response to nutrient stress.

Review 4. Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.

Review 5. Revealing macropinocytosis using nanoparticles.

Review 6. Harnessing metabolic dependencies in pancreatic cancers.

Review 7. Metabolic Codependencies in the Tumor Microenvironment.

Review 8. Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment.

9. Cytokine-enhanced cytolytic activity of exosomes from NK Cells.

Review 10. Cancer metabolism: looking forward.