Gabriel Dias Rodrigues1, Eleonora Tobaldini2, Chiara Bellocchi3, Alessandro Santaniello4, Monica Caronni4, Adriana Severino4, Marco Froldi5, Lorenzo Beretta4, Pedro Paulo da Silva Soares1, Nicola Montano6. 1. Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Brazil; National Institute for Science & Technology - INCT (In)activity & Exercise, CNPq, Niterói, (RJ) Rio de Janeiro, Brazil. 2. Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 3. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. 4. Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. 5. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 6. Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: nicola.montano@unimi.it.
Abstract
OBJECTIVE: To compare autonomic heart rate variability (HRV) parameters at rest and during active stand in a population of SSc patients, taking into account SSc subsets age-matched to healthy control subjects. METHODS: Sixty-nine consecutive SSc patients were enrolled in study; these included 12 subjects with early SSc, 39 with limited cutaneous (lcSSc) and 18 with diffuse cutaneous SSc (dcSSc) along with 36 age- and sex-matched healthy controls (HC). ECG and respiration were recorded in supine position and in orthostatism (ORT). HRV analysis was performed on samples of 300 beats. Spectral analysis identified two oscillatory components, low frequency (LFnu, sympathetic) and high frequency (HFnu, vagal). Symbolic analysis identified three patterns, 0 V%, (sympathetic) and 2UV% and 2LV%, (vagal). The %∆ORT was calculated from the differences between HRV in ORT and SUP, normalized (%) by the HRV values at rest. RESULTS: SSc as a whole had higher markers of sympathetic (LF, 0 V%) and lower markers of vagal modulation (HR, 2UV%, 2LV%) compared to HCs. In addition, %∆LFnu, %∆HFnu, %∆0 V, %∆2UV and %∆2LV were lower in SSc than HC. dcSSc and lcSSc were dissimilar to HC as far as rest indexes were concerned (↑LF/HF, ↑LFnu, ↓HFnu, ↑0 V% and ↓2UV%) while no differences could be detected between HC and EaSSc. CONCLUSION: SSc showed a reduced vagal and increased sympathetic modulation at rest and a blunted autonomic response to ORT in comparison to HC. These alterations were mostly detectable in the advanced and fibrotic forms of SSc (dcSSc and lcSSc), while EaSSc were similar to HC.
OBJECTIVE: To compare autonomic heart rate variability (HRV) parameters at rest and during active stand in a population of SSc patients, taking into account SSc subsets age-matched to healthy control subjects. METHODS: Sixty-nine consecutive SSc patients were enrolled in study; these included 12 subjects with early SSc, 39 with limited cutaneous (lcSSc) and 18 with diffuse cutaneous SSc (dcSSc) along with 36 age- and sex-matched healthy controls (HC). ECG and respiration were recorded in supine position and in orthostatism (ORT). HRV analysis was performed on samples of 300 beats. Spectral analysis identified two oscillatory components, low frequency (LFnu, sympathetic) and high frequency (HFnu, vagal). Symbolic analysis identified three patterns, 0 V%, (sympathetic) and 2UV% and 2LV%, (vagal). The %∆ORT was calculated from the differences between HRV in ORT and SUP, normalized (%) by the HRV values at rest. RESULTS: SSc as a whole had higher markers of sympathetic (LF, 0 V%) and lower markers of vagal modulation (HR, 2UV%, 2LV%) compared to HCs. In addition, %∆LFnu, %∆HFnu, %∆0 V, %∆2UV and %∆2LV were lower in SSc than HC. dcSSc and lcSSc were dissimilar to HC as far as rest indexes were concerned (↑LF/HF, ↑LFnu, ↓HFnu, ↑0 V% and ↓2UV%) while no differences could be detected between HC and EaSSc. CONCLUSION: SSc showed a reduced vagal and increased sympathetic modulation at rest and a blunted autonomic response to ORT in comparison to HC. These alterations were mostly detectable in the advanced and fibrotic forms of SSc (dcSSc and lcSSc), while EaSSc were similar to HC.
Authors: Gabriel Dias Rodrigues; Jonas Lírio Gurgel; Antonio Claudio Lucas da Nobrega; Pedro Paulo da Silva Soares Journal: Eur J Appl Physiol Date: 2022-06-18 Impact factor: 3.346
Authors: Gabriel D Rodrigues; Marco Vicenzi; Chiara Bellocchi; Lorenzo Beretta; Angelica Carandina; Eleonora Tobaldini; Stefano Carugo; Nicola Montano Journal: Front Cardiovasc Med Date: 2022-07-01
Authors: Eleonora Tobaldini; Gabriel D Rodrigues; Giorgio Mantoan; Alice Monti; Giulia Coti Zelati; Camilla Cirelli; Paolo Tarsia; Letizia Corinna Morlacchi; Valeria Rossetti; Ilaria Righi; Mario Nosotti; Pedro Paulo da S Soares; Nicola Montano; Stefano Aliberti; Francesco Blasi Journal: J Clin Med Date: 2020-04-17 Impact factor: 4.241
Authors: Angelica Carandina; Chiara Bellocchi; Gabriel Dias Rodrigues; Lorenzo Beretta; Nicola Montano; Eleonora Tobaldini Journal: Int J Environ Res Public Health Date: 2021-02-25 Impact factor: 3.390