Literature DB >> 3120197

Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.

D I Barry1, I Kikvadze, P Brundin, T G Bolwig, A Björklund, O Lindvall.   

Abstract

Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions.

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Year:  1987        PMID： 3120197      PMCID： PMC299616          DOI： 10.1073/pnas.84.23.8712

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat.

Authors:  P S Arnold; R J Racine; R A Wise
Journal:  Exp Neurol       Date:  1973-08       Impact factor: 5.330

2.  Modification of seizure activity by electrical stimulation. II. Motor seizure.

Authors:  R J Racine
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1972-03

3.  Potentiation of amygdala kindling in adult or infants rats by injections of 6-hydroxydopamine.

Authors:  D C McIntyre; M Saari; B A Pappas
Journal:  Exp Neurol       Date:  1979-03       Impact factor: 5.330

4.  Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats.

Authors:  M E Corcoran; H C Fibiger; J A McCaughran; J A Wada
Journal:  Exp Neurol       Date:  1974-10       Impact factor: 5.330

5.  Amygdala kindling in rats: facilitation after local amygdala norepinephrine depletion with 6-hydroxydopamine.

Authors:  D C McIntyre
Journal:  Exp Neurol       Date:  1980-08       Impact factor: 5.330

6.  A permanent change in brain function resulting from daily electrical stimulation.

Authors:  G V Goddard; D C McIntyre; C K Leech
Journal:  Exp Neurol       Date:  1969-11       Impact factor: 5.330

7.  Role of forebrain catecholamines in amygdaloid kindling.

Authors:  M E Corcoran; S T Mason
Journal:  Brain Res       Date:  1980-05-26       Impact factor: 3.252

8.  Relative frequency of different types of epilepsy: a study employing the classification of the International League Against Epilepsy.

Authors:  H Gastaut; J L Gastaut; G E Gonçalves e Silva; G R Fernandez Sanchez
Journal:  Epilepsia       Date:  1975-09       Impact factor: 5.864

9.  Functional reinnervation of rat hippocampus by locus coeruleus implants.

Authors:  A Björklund; M Segal; U Stenevi
Journal:  Brain Res       Date:  1979-07-20       Impact factor: 3.252

10.  Cell suspension grafts of noradrenergic locus coeruleus neurons in rat hippocampus and spinal cord: reinnervation and transmitter turnover.

Authors:  A Björklund; H Nornes; F H Gage
Journal:  Neuroscience       Date:  1986-07       Impact factor: 3.590
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  16 in total

Review 1.  Transplantation into the human brain: present status and future possibilities.

Authors:  O Lindvall
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-06       Impact factor: 10.154

2.  Intraparenchymal grafting of cerebellar cell suspensions to the deep cerebellar nuclei of pcd mutant mice, with particular emphasis on re-establishment of a Purkinje cell cortico-nuclear projection.

Authors:  L C Triarhou; W C Low; B Ghetti
Journal:  Anat Embryol (Berl)       Date:  1992

Review 3.  Commentary: the prospect of cell-based therapy for epilepsy.

Authors:  Arnold R Kriegstein; Asla Pitkänen
Journal:  Neurotherapeutics       Date:  2009-04       Impact factor: 7.620

4.  Differentiation of neurons in the locus ceruleus after allotransplantation into previously denervated white rat hippocampus.

Authors:  I K Svanidze; Ts S Tsaishvili; Z G Kokaya; S B Godziashvili; M G Kokaya
Journal:  Neurosci Behav Physiol       Date:  1998 Jul-Aug

5.  Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats.

Authors:  Janusz Szyndler; Piotr Maciejak; Danuta Turzyńska; Alicja Sobolewska; Andrzej Bidziński; Adam Płaźnik
Journal:  J Neural Transm (Vienna)       Date:  2010-05-07       Impact factor: 3.575

6.  Suppression and induction of epileptic activity by neuronal grafts.

Authors:  G Buzsáki; G Ponomareff; F Bayardo; T Shaw; F H Gage
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

Review 7.  Transplantation of fetal cells and tissue: an overview.

Authors:  A Fine
Journal:  CMAJ       Date:  1994-11-01       Impact factor: 8.262

8.  Genetic comparison of seizure control by norepinephrine and neuropeptide Y.

Authors:  D Weinshenker; P Szot; N S Miller; N C Rust; J G Hohmann; U Pyati; S S White; R D Palmiter
Journal:  J Neurosci       Date:  2001-10-01       Impact factor: 6.167

9.  Neonatal domoic acid alters in vivo binding of [11C]yohimbine to α2-adrenoceptors in adult rat brain.

Authors:  Majken B Thomsen; Thea P Lillethorup; Steen Jakobsen; Erik H Nielsen; Mette Simonsen; Gregers Wegener; Anne M Landau; R Andrew Tasker
Journal:  Psychopharmacology (Berl)       Date:  2016-08-25       Impact factor: 4.530

10.  Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices.

Authors:  M Kokaia; P Aebischer; E Elmér; J Bengzon; P Kalén; Z Kokaia; O Lindvall
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972
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