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Literature DB >> 19332322

Commentary: the prospect of cell-based therapy for epilepsy.

Abstract

About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel approaches are needed to prevent or alleviate epileptogenic process after various types of brain injuries. The use of cell transplants as factories to produce endogeneous anticonvulsants or as bricks to repair abnormal ictogenic and epileptogenic neuronal circuits has generated hope that cell-based therapies could become a novel therapeutic category in the treatment arsenal of epilepsy. Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy.

Entities: Disease Species

Mesh：

Year: 2009 PMID： 19332322 PMCID： PMC5084206 DOI： 10.1016/j.nurt.2009.01.013

Source DB: PubMed Journal: Neurotherapeutics ISSN： 1878-7479 Impact factor: 7.620

37 in total

1. Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures.

Authors: K Thompson; V Anantharam; S Behrstock; E Bongarzone; A Campagnoni; A J Tobin
Journal: Exp Neurol Date: 2000-02 Impact factor: 5.330

2. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.

Authors: Manuel Alvarez-Dolado; Maria Elisa Calcagnotto; Kameel M Karkar; Derek G Southwell; Dorothy M Jones-Davis; Rosanne C Estrada; John L R Rubenstein; Arturo Alvarez-Buylla; Scott C Baraban
Journal: J Neurosci Date: 2006-07-12 Impact factor: 6.167

3. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.

Authors: W Löscher; U Ebert; H Lehmann; C Rosenthal; G Nikkhah
Journal: J Neurosci Res Date: 1998-01-15 Impact factor: 4.164

4. Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex.

Authors: J Tuunanen; T Halonen; A Pitkänen
Journal: Eur J Neurosci Date: 1996-12 Impact factor: 3.386

Review 5. Cell and gene therapies in epilepsy--promising avenues or blind alleys?

Authors: Wolfgang Löscher; Manuela Gernert; Uwe Heinemann
Journal: Trends Neurosci Date: 2008-01-16 Impact factor: 13.837

6. Effect of neural transplants on seizure frequency and kindling in immature rats following kainic acid.

Authors: G L Holmes; J L Thompson; K Huh; C Holmes; G F Carl
Journal: Brain Res Dev Brain Res Date: 1991-12-17

7. Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy.

Authors: Bharathi Hattiangady; Muddanna S Rao; Ashok K Shetty
Journal: Exp Neurol Date: 2008-05-15 Impact factor: 5.330

Commentary: the prospect of cell-based therapy for epilepsy.

1. Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures.

2. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.

3. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.

4. Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex.

Review 5. Cell and gene therapies in epilepsy--promising avenues or blind alleys?

6. Effect of neural transplants on seizure frequency and kindling in immature rats following kainic acid.

7. Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy.

8. Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy.

9. Suppression of kindling epileptogenesis in rats by intrahippocampal cholinergic grafts.

10. The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.

1. The fraction of cortical GABAergic neurons is constant from near the start of cortical neurogenesis to adulthood.

Review 2. GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity.