Literature DB >> 3120177

Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.

R B Winter1, L Morrissey, P Gauss, L Gold, T Hsu, J Karam.   

Abstract

The bacteriophage T4 regA protein is a translational repressor of a subset of phage mRNAs. We show here that purified regA protein binds specifically to target mRNAs near the initiating AUG and occludes binding of ribosomes. Translational repression by regA protein diminishes expression of many genes whose mRNA sequences around the initiating AUG codons are different. A comparison of nucleotide sequences from several regA-repressed mRNAs suggests that the initiating AUG is an important, but not sufficient, sequence for regA binding.

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Year:  1987        PMID： 3120177      PMCID： PMC299406          DOI： 10.1073/pnas.84.22.7822

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Level of specific prereplicative mRNA's during bacteriophage T4 regA-, 43- and T4 43- infection of Escherichia coli B.

Authors:  R B Trimble
Journal:  J Virol       Date:  1976-02       Impact factor: 5.103

2.  Genetic control of mRNA decay in T4 phage-infected Escherichia coli.

Authors:  J Karam; C McCulley; M Leach
Journal:  Virology       Date:  1977-02       Impact factor: 3.616

3.  SP62, a viable mutant of bacteriophage T4D defective in regulation of phage enzyme synthesis.

Authors:  J S Wiberg; S Mendelsohn; V Warner; K Hercules; C Aldrich; J L Munro
Journal:  J Virol       Date:  1973-10       Impact factor: 5.103

4.  The subunit interface of the Escherichia coli ribosome. Crosslinking of 30 S protein S9 to proteins of the 50 S subunit.

Authors:  J W Kenny; T G Fanning; J M Lambert; R R Traut
Journal:  J Mol Biol       Date:  1979-11-25       Impact factor: 5.469

5.  Binding site on R17 RNA for coat protein.

Authors:  P F Spahr; M Farber; R F Gesteland
Journal:  Nature       Date:  1969-05-03       Impact factor: 49.962

6.  rII cistrons of bacteriophage T4. DNA sequence around the intercistronic divide and positions of genetic landmarks.

Authors:  D Pribnow; D C Sigurdson; L Gold; B S Singer; C Napoli; J Brosius; T J Dull; H F Noller
Journal:  J Mol Biol       Date:  1981-07-05       Impact factor: 5.469

Review 7.  Interaction of R17 coat protein with its RNA binding site for translational repression.

Authors:  O C Uhlenbeck; J Carey; P J Romaniuk; P T Lowary; D Beckett
Journal:  J Biomol Struct Dyn       Date:  1983-10

8.  The generation and analysis of clones containing bacteriophage T4 DNA fragments.

Authors:  J Velten; J Abelson
Journal:  J Mol Biol       Date:  1980-02-25       Impact factor: 5.469

9.  Autogenous translational repression of bacteriophage T4 gene 32 expression in vitro.

Authors:  G Lemaire; L Gold; M Yarus
Journal:  J Mol Biol       Date:  1978-11-25       Impact factor: 5.469

10.  Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function.

Authors:  J Karam; L Gold; B S Singer; M Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205
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  36 in total

1.  Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding.

Authors:  O Vytvytska; I Moll; V R Kaberdin; A von Gabain; U Bläsi
Journal:  Genes Dev       Date:  2000-05-01       Impact factor: 11.361

2.  Mutational analysis of the mRNA operator for T4 DNA polymerase.

Authors:  M D Andrake; J D Karam
Journal:  Genetics       Date:  1991-06       Impact factor: 4.562

3.  Regions of bacteriophage T4 and RB69 RegA translational repressor proteins that determine RNA-binding specificity.

Authors:  C E Jozwik; E S Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

4.  Binding of the bacteriophage T4 regA protein to mRNA targets: an initiator AUG is required.

Authors:  S Unnithan; L Green; L Morrissey; J Binkley; B Singer; J Karam; L Gold
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

5.  Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX.

Authors:  D Kornitzer; D Teff; S Altuvia; A B Oppenheim
Journal:  J Bacteriol       Date:  1991-05       Impact factor: 3.490

6.  The rIIA gene of bacteriophage T4. I. Its DNA sequence and discovery of a new open reading frame between genes 60 and rIIA.

Authors:  P Daegelen; E Brody
Journal:  Genetics       Date:  1990-06       Impact factor: 4.562

7.  Ribosomal protein S15 from Escherichia coli modulates its own translation by trapping the ribosome on the mRNA initiation loading site.

Authors:  C Philippe; F Eyermann; L Bénard; C Portier; B Ehresmann; C Ehresmann
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

8.  Sequence analysis of conserved regA and variable orf43.1 genes in T4-like bacteriophages.

Authors:  E S Miller; C E Jozwik
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

9.  Functional recognition of fragmented operator sites by R17/MS2 coat protein, a translational repressor.

Authors:  D E Fouts; H L True; D W Celander
Journal:  Nucleic Acids Res       Date:  1997-11-15       Impact factor: 16.971

10.  Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.

Authors:  D M Voeller; L M Changchien; G F Maley; F Maley; T Takechi; R E Turner; W R Montfort; C J Allegra; E Chu
Journal:  Nucleic Acids Res       Date:  1995-03-11       Impact factor: 16.971
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