Literature DB >> 31201633

Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins.

V Z Lankin1, M G Sharapov2, R G Goncharov2, A K Tikhaze3, V I Novoselov2.   

Abstract

It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.

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Year:  2019        PMID： 31201633     DOI： 10.1134/S1607672919020157

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

Review 1.  Peroxiredoxins.

Authors:  Birgit Hofmann; Hans-Jürgen Hecht; Leopold Flohé
Journal:  Biol Chem       Date:  2002 Mar-Apr       Impact factor: 3.915

2.  Protein and low molecular mass thiols as targets and inhibitors of glycation reactions.

Authors:  Jingmin Zeng; Michael J Davies
Journal:  Chem Res Toxicol       Date:  2006-12       Impact factor: 3.739

3.  Enzymatic antioxidant system of endotheliocytes.

Authors:  M G Sharapov; R G Goncharov; A E Gordeeva; V I Novoselov; O A Antonova; A K Tikhaze; V Z Lankin
Journal:  Dokl Biochem Biophys       Date:  2017-01-06       Impact factor: 0.788

4.  Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis.

Authors:  V L Kinnula; S Lehtonen; R Kaarteenaho-Wiik; E Lakari; P Pääkkö; S W Kang; S G Rhee; Y Soini
Journal:  Thorax       Date:  2002-02       Impact factor: 9.139

5.  Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions.

Authors:  A Okado-Matsumoto; A Matsumoto; J Fujii; N Taniguchi
Journal:  J Biochem       Date:  2000-03       Impact factor: 3.387

6.  Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate.

Authors:  M S Seo; S W Kang; K Kim; I C Baines; T H Lee; S G Rhee
Journal:  J Biol Chem       Date:  2000-07-07       Impact factor: 5.157

7.  Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities.

Authors:  Yefim Manevich; Tea Shuvaeva; Chandra Dodia; Altaf Kazi; Sheldon I Feinstein; Aron B Fisher
Journal:  Arch Biochem Biophys       Date:  2009-02-21       Impact factor: 4.013

8.  The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes.

Authors:  Vadim Lankin; Galina Konovalova; Alla Tikhaze; Konstantin Shumaev; Elena Kumskova; Margus Viigimaa
Journal:  Mol Cell Biochem       Date:  2014-07-05       Impact factor: 3.396

Review 9.  Structure, mechanism and regulation of peroxiredoxins.

Authors:  Zachary A Wood; Ewald Schröder; J Robin Harris; Leslie B Poole
Journal:  Trends Biochem Sci       Date:  2003-01       Impact factor: 13.807

Review 10.  Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease.

Authors:  Sarah J Chapple; Xinghua Cheng; Giovanni E Mann
Journal:  Redox Biol       Date:  2013-05-23       Impact factor: 11.799
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  1 in total

Review 1.  Dicarbonyl-Dependent Modification of LDL as a Key Factor of Endothelial Dysfunction and Atherosclerotic Vascular Wall Damage.

Authors:  Vadim Z Lankin; Alla K Tikhaze; Arthur M Melkumyants
Journal:  Antioxidants (Basel)       Date:  2022-08-12
  1 in total

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