Sizheng Steven Zhao1,2, David M Hughes3. 1. Musculoskeletal Biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. stevenzhao25@gmail.com. 2. Department of Academic Rheumatology, Aintree University Hospital, Liverpool, UK. stevenzhao25@gmail.com. 3. Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.