Sizheng Zhao1,2, Stephen J Duffield3, David M Hughes4. 1. Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. stevenzhao25@gmail.com. 2. Department of Academic Rheumatology, Aintree University Hospital, Liverpool, UK. stevenzhao25@gmail.com. 3. Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. 4. Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.