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Literature DB >> 3119763

Isolation and characterization of a light chain variable region gene for human rheumatoid factors.

P P Chen¹, D L Robbins, F R Jirik, T J Kipps, D A Carson.

Abstract

Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3119763 PMCID： PMC2188786 DOI： 10.1084/jem.166.6.1900

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

15 in total

1. Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.

Authors: P P Chen; K Albrandt; N K Orida; V Radoux; E Y Chen; R Schrantz; F T Liu; D A Carson
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

2. Cloning and sequence determination of a human rheumatoid factor light-chain gene.

Authors: F R Jirik; J Sorge; S Fong; J G Heitzmann; J G Curd; P P Chen; R Goldfien; D A Carson
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

3. Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.

Authors: P P Chen; K Albrandt; T J Kipps; V Radoux; F T Liu; D A Carson
Journal: J Immunol Date: 1987-09-01 Impact factor: 5.422

4. Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies.

Authors: D K Ledford; F Goñi; M Pizzolato; E C Franklin; A Solomon; B Frangione
Journal: J Immunol Date: 1983-09 Impact factor: 5.422

5. Immunoglobulin genes of different subgroups are interdigitated within the VK locus.

Authors: M Pech; H G Zachau
Journal: Nucleic Acids Res Date: 1984-12-21 Impact factor: 16.971

6. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.

Authors: H G Kunkel; V Agnello; F G Joslin; R J Winchester; J D Capra
Journal: J Exp Med Date: 1973-02-01 Impact factor: 14.307

7. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

Authors: Y Naparstek; J André-Schwartz; T Manser; L J Wysocki; L Breitman; B D Stollar; M Gefter; R S Schwartz
Journal: J Exp Med Date: 1986-08-01 Impact factor: 14.307

8. Sequence similarities among kappa IIIb chains of monoclonal human IgM kappa autoantibodies.

Authors: B Pons-Estel; F Goñi; A Solomon; B Frangione
Journal: J Exp Med Date: 1984-09-01 Impact factor: 14.307

9. Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells.

Authors: M J Shlomchik; D A Nemazee; V L Sato; J Van Snick; D A Carson; M G Weigert
Journal: J Exp Med Date: 1986-08-01 Impact factor: 14.307

10. A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

Authors: V Radoux; P P Chen; J A Sorge; D A Carson
Journal: J Exp Med Date: 1986-12-01 Impact factor: 14.307

28 in total

1. Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.

Authors: J M Bye; C Carter; Y Cui; B D Gorick; S Songsivilai; G Winter; N C Hughes-Jones; J D Marks
Journal: J Clin Invest Date: 1992-12 Impact factor: 14.808

2. Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.

Authors: George F Widhopf; Craig J Goldberg; Traci L Toy; Laura Z Rassenti; William G Wierda; John C Byrd; Michael J Keating; John G Gribben; Kanti R Rai; Thomas J Kipps
Journal: Blood Date: 2007-08-03 Impact factor: 22.113

3. Evidence that the V kappa III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal.

Authors: J C Weber; G Blaison; T Martin; A M Knapp; J L Pasquali
Journal: J Clin Invest Date: 1994-05 Impact factor: 14.808

4. Rheumatoid factors: where are we now?

Authors: A I Soltys; J S Axford; B J Sutton
Journal: Ann Rheum Dis Date: 1997-05 Impact factor: 19.103

5. A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.

Authors: P P Chen; K A Siminovitch; N J Olsen; R A Erger; D A Carson
Journal: J Clin Invest Date: 1989-08 Impact factor: 14.808

10. VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection.

Authors: H Ikematsu; Y Ichiyoshi; E W Schettino; M Nakamura; P Casali
Journal: J Immunol Date: 1994-02-01 Impact factor: 5.422