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Literature DB >> 3119721

How immunoglobulin V kappa genes rearrange.

Abstract

Recombination at the immunoglobulin kappa light chain locus creates a complete variable region gene and its reciprocal product. The results presented here show that reciprocal products may be substrates for secondary recombination and that at least one V kappa group rearranges by inversion.

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Year: 1987 PMID： 3119721

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

31 in total

Review 1. Receptor selection in B and T lymphocytes.

Authors: D Nemazee
Journal: Annu Rev Immunol Date: 2000 Impact factor: 28.527

Review 2. Allelic exclusion of immunoglobulin genes: models and mechanisms.

Authors: Christian Vettermann; Mark S Schlissel
Journal: Immunol Rev Date: 2010-09 Impact factor: 12.988

Review 3. Somatic diversification of antibody responses.

Authors: B Zheng; G Kelsoe; S Han
Journal: J Clin Immunol Date: 1996-01 Impact factor: 8.317

4. Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.

Authors: A M Lawler; J F Kearney; M Kuehl; P J Gearhart
Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

How immunoglobulin V kappa genes rearrange.

Review 1. Receptor selection in B and T lymphocytes.

Review 2. Allelic exclusion of immunoglobulin genes: models and mechanisms.

Review 3. Somatic diversification of antibody responses.

4. Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.

5. Direct evidence for intrastrand DNA inversion of kappa immunoglobulin gene segments in two murine plasmacytomas.

6. The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6.

7. Rapid cloning of any rearranged mouse immunoglobulin variable genes.

Review 8. B cell receptor editing in tolerance and autoimmunity.

9. The complexity of expressed kappa light chains in egg-laying mammals.

10. Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells.