Literature DB >> 2513557

Direct evidence for intrastrand DNA inversion of kappa immunoglobulin gene segments in two murine plasmacytomas.

R Feddersen1, B Van Ness.   

Abstract

The products of kappa immunoglobulin gene recombination have been characterized in two murine plasmacytomas to examine the relationship between V-J products and reciprocal elements. By cloning, sequencing, hybridization, and application of the polymerase chain reaction, we have established the direct relationship of the kappa recombination products in these cells. The results provide stronger support for the intrastrand mechanism of kappa gene recombination as well as demonstrating a role for secondary, corrective recombinations.

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Year:  1989        PMID： 2513557      PMCID： PMC335214          DOI： 10.1093/nar/17.23.9797

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  19 in total

Review 1.  Molecular characterization of the lymphoid V(D)J recombination activity.

Authors:  T K Blackwell; F W Alt
Journal:  J Biol Chem       Date:  1989-06-25       Impact factor: 5.157

2.  Physical map of the human immunoglobulin K locus and its implications for the mechanisms of VK-JK rearrangement.

Authors:  W Lorenz; B Straubinger; H G Zachau
Journal:  Nucleic Acids Res       Date:  1987-12-10       Impact factor: 16.971

3.  Linking of the human immunoglobulin VK and JKCK regions by chromosomal walking.

Authors:  H G Klobeck; F J Zimmer; G Combriato; H G Zachau
Journal:  Nucleic Acids Res       Date:  1987-12-10       Impact factor: 16.971

4.  The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.

Authors:  E E Max; J V Maizel; P Leder
Journal:  J Biol Chem       Date:  1981-05-25       Impact factor: 5.157

5.  Two rearranged immunoglobulin kappa light chain genes in one mouse myeloma.

Authors:  M Steinmetz; H G Zachau
Journal:  Nucleic Acids Res       Date:  1980-04-25       Impact factor: 16.971

6.  Reorganization and expression of immunoglobulin genes: status of allelic elements.

Authors:  R P Perry; C Coleclough; M Weigert
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1981

7.  DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.

Authors:  B G Van Ness; C Coleclough; R P Perry; M Weigert
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

8.  Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.

Authors:  C Coleclough; R P Perry; K Karjalainen; M Weigert
Journal:  Nature       Date:  1981-04-02       Impact factor: 49.962

9.  Myeloma proteins from NZB and BALB/c mice: structural and functional differences.

Authors:  E Loh; B Black; R Riblet; M Weigert; J M Hood; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

10.  Recombined flanks of the variable and joining segments of immunoglobulin genes.

Authors:  J Höchtl; C R Müller; H G Zachau
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205
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