Literature DB >> 31191872

Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1.

Benjamin C Giglio1, Hui Wang1, Xuefeng Yan1, Zibo Li1.   

Abstract

A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The in vivo distribution and imaging potential of 5-I-AMT were explored with a B16F10 tumor model using I-124 as the radiotag.

Entities:  

Year:  2019        PMID： 31191872      PMCID： PMC6540958          DOI： 10.1039/c9md00082h

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  14 in total

Review 1.  Modulating Tumor Immunology by Inhibiting Indoleamine 2,3-Dioxygenase (IDO): Recent Developments and First Clinical Experiences.

Authors:  Diwakar Davar; Nathan Bahary
Journal:  Target Oncol       Date:  2018-04       Impact factor: 4.493

2.  Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp.

Authors:  M Diksic; Y Tohyama; A Takada
Journal:  Neurochem Res       Date:  2000-12       Impact factor: 3.996

3.  Pembrolizumab versus Ipilimumab in Advanced Melanoma.

Authors:  Caroline Robert; Jacob Schachter; Georgina V Long; Ana Arance; Jean Jacques Grob; Laurent Mortier; Adil Daud; Matteo S Carlino; Catriona McNeil; Michal Lotem; James Larkin; Paul Lorigan; Bart Neyns; Christian U Blank; Omid Hamid; Christine Mateus; Ronnie Shapira-Frommer; Michele Kosh; Honghong Zhou; Nageatte Ibrahim; Scot Ebbinghaus; Antoni Ribas
Journal:  N Engl J Med       Date:  2015-04-19       Impact factor: 91.245

4.  Increased tryptophan uptake on PET has strong independent prognostic value in patients with a previously treated high-grade glioma.

Authors:  David O Kamson; Sandeep Mittal; Natasha L Robinette; Otto Muzik; William J Kupsky; Geoffrey R Barger; Csaba Juhász
Journal:  Neuro Oncol       Date:  2014-03-26       Impact factor: 12.300

Review 5.  Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan.

Authors:  M Diksic; S N Young
Journal:  J Neurochem       Date:  2001-09       Impact factor: 5.372

6.  Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.

Authors:  Edit Bosnyák; David O Kamson; Anthony R Guastella; Kaushik Varadarajan; Natasha L Robinette; William J Kupsky; Otto Muzik; Sharon K Michelhaugh; Sandeep Mittal; Csaba Juhász
Journal:  Neuro Oncol       Date:  2015-06-18       Impact factor: 12.300

7.  First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies.

Authors:  Gregory L Beatty; Peter J O'Dwyer; Jason Clark; Jack G Shi; Kevin J Bowman; Peggy A Scherle; Robert C Newton; Richard Schaub; Janet Maleski; Lance Leopold; Thomas F Gajewski
Journal:  Clin Cancer Res       Date:  2017-01-04       Impact factor: 12.531

8.  Indoleamine 2,3-dioxygenase is necessary for cytolytic activity of natural killer cells.

Authors:  S Kai; S Goto; K Tahara; A Sasaki; S Tone; S Kitano
Journal:  Scand J Immunol       Date:  2004-02       Impact factor: 3.487

9.  Synthesis of 5-[18F]Fluoro-α-methyl Tryptophan: New Trp Based PET Agents.

Authors:  Benjamin C Giglio; Haiyang Fei; Mengzhe Wang; Hui Wang; Liu He; Huijuan Feng; Zhanhong Wu; Hongjian Lu; Zibo Li
Journal:  Theranostics       Date:  2017-04-07       Impact factor: 11.556

10.  Targeting telomerase with radiolabeled inhibitors.

Authors:  Philip A Waghorn; Mark R Jackson; Veronique Gouverneur; Katherine A Vallis
Journal:  Eur J Med Chem       Date:  2016-09-10       Impact factor: 7.088
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