Olivia A J Begasse de Dhaem1, Jacqueline French2, Chris Morrison2, Kimford J Meador3, Dale C Hesdorffer4, Sabrina Cristofaro2, Mia T Minen5. 1. New York Presbyterian Hospital Columbia University, 710 W 168th Street, 14th Floor, Ericka Ayala's Office, New York, NY 10032, USA. Electronic address: oab2109@cumc.columbia.edu. 2. New York University School of Medicine, NYU Langone Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY 10016, USA. 3. Stanford University Neuroscience Health Center, 213 Quarry Rd Rm 2851, MC 5957, Palo Alto, CA 94304, USA. 4. Gertrude H.K Sergievsky Center and Department of Epidemiology, Columbia University, 630 West 168th Street, P & S unit 16, PH19, Room 308, New York, NY 10032, USA. 5. New York University School of Medicine, NYU Langone Headache Center, 222 East 41st Street, New York, NY 10017, USA.
Abstract
BACKGROUND: Migraine and epilepsy are comorbid conditions. While it is well known that epilepsy can have an impact on cognitive abilities, there is conflicting evidence in the literature on the relationship between migraine and cognitive function. The aim of this study was to assess whether migraine comorbidity in patients with newly diagnosed focal epilepsy is associated with cognitive dysfunction. METHODS: This is a post hoc analysis of data prospectively collected for the Human Epilepsy Project (HEP). There were 349 participants screened for migraine with the 13 questions used in the American Migraine Prevalence and Prevention (AMPP) study. Participants were also screened for depression using the Neurological Disorder Depression Inventory for Epilepsy (NDDI-E) and the Center for Epidemiologic Studies Depression Scale (CES-D) and for anxiety using the Generalized Anxiety Disorder-7 (GAD-7) scale. Cognitive performance was assessed with the Cogstate Brief Battery and Aldenkamp-Baker Neuropsychological Assessment Schedule (ABNAS). RESULTS: About a fifth (21.2%) of patients with a new diagnosis of focal epilepsy screened positive for migraine. There were more women and less participants employed full time among the participants with comorbid migraine. They reported slightly more depressive and anxious symptoms than the participants without migraine. Migraine comorbidity was associated with ABNAS memory score (median: 2, range: 0-12, Mann Whitney U p-value: 0.015). However, migraine comorbidity was not associated with Cogstate scores nor ABNAS total scores or other ABNAS domain scores. In linear regressions, depression and anxiety scores were associated with the ABNAS memory score. CONCLUSION: In this study, there was no association between migraine comorbidity and objective cognitive scores in patients with newly diagnosed focal epilepsy. The relationship between migraine comorbidity and subjective memory deficits seemed to be mediated by the higher prevalence of depression and anxiety symptoms in patients with epilepsy with comorbid migraine.
BACKGROUND:Migraine and epilepsy are comorbid conditions. While it is well known that epilepsy can have an impact on cognitive abilities, there is conflicting evidence in the literature on the relationship between migraine and cognitive function. The aim of this study was to assess whether migraine comorbidity in patients with newly diagnosed focal epilepsy is associated with cognitive dysfunction. METHODS: This is a post hoc analysis of data prospectively collected for the HumanEpilepsy Project (HEP). There were 349 participants screened for migraine with the 13 questions used in the American Migraine Prevalence and Prevention (AMPP) study. Participants were also screened for depression using the Neurological Disorder Depression Inventory for Epilepsy (NDDI-E) and the Center for Epidemiologic Studies Depression Scale (CES-D) and for anxiety using the Generalized Anxiety Disorder-7 (GAD-7) scale. Cognitive performance was assessed with the Cogstate Brief Battery and Aldenkamp-Baker Neuropsychological Assessment Schedule (ABNAS). RESULTS: About a fifth (21.2%) of patients with a new diagnosis of focal epilepsy screened positive for migraine. There were more women and less participants employed full time among the participants with comorbid migraine. They reported slightly more depressive and anxious symptoms than the participants without migraine. Migraine comorbidity was associated with ABNAS memory score (median: 2, range: 0-12, Mann Whitney U p-value: 0.015). However, migraine comorbidity was not associated with Cogstate scores nor ABNAS total scores or other ABNAS domain scores. In linear regressions, depression and anxiety scores were associated with the ABNAS memory score. CONCLUSION: In this study, there was no association between migraine comorbidity and objective cognitive scores in patients with newly diagnosed focal epilepsy. The relationship between migraine comorbidity and subjective memory deficits seemed to be mediated by the higher prevalence of depression and anxiety symptoms in patients with epilepsy with comorbid migraine.
Authors: Verneri Anttila; Brendan Bulik-Sullivan; Hilary K Finucane; Raymond K Walters; Jose Bras; Laramie Duncan; Valentina Escott-Price; Guido J Falcone; Padhraig Gormley; Rainer Malik; Nikolaos A Patsopoulos; Stephan Ripke; Zhi Wei; Dongmei Yu; Phil H Lee; Patrick Turley; Benjamin Grenier-Boley; Vincent Chouraki; Yoichiro Kamatani; Claudine Berr; Luc Letenneur; Didier Hannequin; Philippe Amouyel; Anne Boland; Jean-François Deleuze; Emmanuelle Duron; Badri N Vardarajan; Christiane Reitz; Alison M Goate; Matthew J Huentelman; M Ilyas Kamboh; Eric B Larson; Ekaterina Rogaeva; Peter St George-Hyslop; Hakon Hakonarson; Walter A Kukull; Lindsay A Farrer; Lisa L Barnes; Thomas G Beach; F Yesim Demirci; Elizabeth Head; Christine M Hulette; Gregory A Jicha; John S K Kauwe; Jeffrey A Kaye; James B Leverenz; Allan I Levey; Andrew P Lieberman; Vernon S Pankratz; Wayne W Poon; Joseph F Quinn; Andrew J Saykin; Lon S Schneider; Amanda G Smith; Joshua A Sonnen; Robert A Stern; Vivianna M Van Deerlin; Linda J Van Eldik; Denise Harold; Giancarlo Russo; David C Rubinsztein; Anthony Bayer; Magda Tsolaki; Petra Proitsi; Nick C Fox; Harald Hampel; Michael J Owen; Simon Mead; Peter Passmore; Kevin Morgan; Markus M Nöthen; Martin Rossor; Michelle K Lupton; Per Hoffmann; Johannes Kornhuber; Brian Lawlor; Andrew McQuillin; Ammar Al-Chalabi; Joshua C Bis; Agustin Ruiz; Mercè Boada; Sudha Seshadri; Alexa Beiser; Kenneth Rice; Sven J van der Lee; Philip L De Jager; Daniel H Geschwind; Matthias Riemenschneider; Steffi Riedel-Heller; Jerome I Rotter; Gerhard Ransmayr; Bradley T Hyman; Carlos Cruchaga; Montserrat Alegret; Bendik Winsvold; Priit Palta; Kai-How Farh; Ester Cuenca-Leon; Nicholas Furlotte; Tobias Kurth; Lannie Ligthart; Gisela M Terwindt; Tobias Freilinger; Caroline Ran; Scott D Gordon; Guntram Borck; Hieab H H Adams; Terho Lehtimäki; Juho Wedenoja; Julie E Buring; Markus Schürks; Maria Hrafnsdottir; Jouke-Jan Hottenga; Brenda Penninx; Ville Artto; Mari Kaunisto; Salli Vepsäläinen; Nicholas G Martin; Grant W Montgomery; Mitja I Kurki; Eija Hämäläinen; Hailiang Huang; Jie Huang; Cynthia Sandor; Caleb Webber; Bertram Muller-Myhsok; Stefan Schreiber; Veikko Salomaa; Elizabeth Loehrer; Hartmut Göbel; Alfons Macaya; Patricia Pozo-Rosich; Thomas Hansen; Thomas Werge; Jaakko Kaprio; Andres Metspalu; Christian Kubisch; Michel D Ferrari; Andrea C Belin; Arn M J M van den Maagdenberg; John-Anker Zwart; Dorret Boomsma; Nicholas Eriksson; Jes Olesen; Daniel I Chasman; Dale R Nyholt; Andreja Avbersek; Larry Baum; Samuel Berkovic; Jonathan Bradfield; Russell J Buono; Claudia B Catarino; Patrick Cossette; Peter De Jonghe; Chantal Depondt; Dennis Dlugos; Thomas N Ferraro; Jacqueline French; Helle Hjalgrim; Jennifer Jamnadas-Khoda; Reetta Kälviäinen; Wolfram S Kunz; Holger Lerche; Costin Leu; Dick Lindhout; Warren Lo; Daniel Lowenstein; Mark McCormack; Rikke S Møller; Anne Molloy; Ping-Wing Ng; Karen Oliver; Michael Privitera; Rodney Radtke; Ann-Kathrin Ruppert; Thomas Sander; Steven Schachter; Christoph Schankin; Ingrid Scheffer; Susanne Schoch; Sanjay M Sisodiya; Philip Smith; Michael Sperling; Pasquale Striano; Rainer Surges; G Neil Thomas; Frank Visscher; Christopher D Whelan; Federico Zara; Erin L Heinzen; Anthony Marson; Felicitas Becker; Hans Stroink; Fritz Zimprich; Thomas Gasser; Raphael Gibbs; Peter Heutink; Maria Martinez; Huw R Morris; Manu Sharma; Mina Ryten; Kin Y Mok; Sara Pulit; Steve Bevan; Elizabeth Holliday; John Attia; Thomas Battey; Giorgio Boncoraglio; Vincent Thijs; Wei-Min Chen; Braxton Mitchell; Peter Rothwell; Pankaj Sharma; Cathie Sudlow; Astrid Vicente; Hugh Markus; Christina Kourkoulis; Joana Pera; Miriam Raffeld; Scott Silliman; Vesna Boraska Perica; Laura M Thornton; Laura M Huckins; N William Rayner; Cathryn M Lewis; Monica Gratacos; Filip Rybakowski; Anna Keski-Rahkonen; Anu Raevuori; James I Hudson; Ted Reichborn-Kjennerud; Palmiero Monteleone; Andreas Karwautz; Katrin Mannik; Jessica H Baker; Julie K O'Toole; Sara E Trace; Oliver S P Davis; Sietske G Helder; Stefan Ehrlich; Beate Herpertz-Dahlmann; Unna N Danner; Annemarie A van Elburg; Maurizio Clementi; Monica Forzan; Elisa Docampo; Jolanta Lissowska; Joanna Hauser; Alfonso Tortorella; Mario Maj; Fragiskos Gonidakis; Konstantinos Tziouvas; Hana Papezova; Zeynep Yilmaz; Gudrun Wagner; Sarah Cohen-Woods; Stefan Herms; Antonio Julià; Raquel Rabionet; Danielle M Dick; Samuli Ripatti; Ole A Andreassen; Thomas Espeseth; Astri J Lundervold; Vidar M Steen; Dalila Pinto; Stephen W Scherer; Harald Aschauer; Alexandra Schosser; Lars Alfredsson; Leonid Padyukov; Katherine A Halmi; James Mitchell; Michael Strober; Andrew W Bergen; Walter Kaye; Jin Peng Szatkiewicz; Bru Cormand; Josep Antoni Ramos-Quiroga; Cristina Sánchez-Mora; Marta Ribasés; Miguel Casas; Amaia Hervas; Maria Jesús Arranz; Jan Haavik; Tetyana Zayats; Stefan Johansson; Nigel Williams; Astrid Dempfle; Aribert Rothenberger; Jonna Kuntsi; Robert D Oades; Tobias Banaschewski; Barbara Franke; Jan K Buitelaar; Alejandro Arias Vasquez; Alysa E Doyle; Andreas Reif; 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