James W Reinhardt1, Juan de Dios Ruiz Rosado2, Jenny C Barker1, Yong-Ung Lee1, Cameron A Best1,3, Tai Yi1, Qiang Zeng1, Santiago Partida-Sanchez2, Toshiharu Shinoka1,4, Christopher K Breuer1,5. 1. Center for Tissue Engineering, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. 2. Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. 3. Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA. 4. Department of Cardiothoracic Surgery, Nationwide Children's Hospital, Columbus, OH 43205, USA. 5. Department of Surgery, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Abstract
Aim: To characterize early events in neotissue formation during the first 2 weeks after vascular scaffold implantation. Materials & methods: Biodegradable polymeric scaffolds were implanted as abdominal inferior vena cava interposition grafts in wild-type mice. Results: All scaffolds explanted at day 1 contained a platelet-rich mural thrombus. Within the first few days, the majority of cell infiltration appeared to be from myeloid cells at the peritoneal surface with modest infiltration along the lumen. Host reaction to the graft was distinct between the scaffold and mural thrombus; the scaffold stimulated an escalating foreign body reaction, whereas the thrombus was quickly remodeled into collagen-rich neotissue. Conclusion: Mural thrombi remodel into neotissue that persistently occludes the lumen of vascular grafts.
Aim: To characterize early events in neotissue formation during the first 2 weeks after vascular scaffold implantation. Materials & methods: Biodegradable polymeric scaffolds were implanted as abdominal inferior vena cava interposition grafts in wild-type mice. Results: All scaffolds explanted at day 1 contained a platelet-rich mural thrombus. Within the first few days, the majority of cell infiltration appeared to be from myeloid cells at the peritoneal surface with modest infiltration along the lumen. Host reaction to the graft was distinct between the scaffold and mural thrombus; the scaffold stimulated an escalating foreign body reaction, whereas the thrombus was quickly remodeled into collagen-rich neotissue. Conclusion: Mural thrombi remodel into neotissue that persistently occludes the lumen of vascular grafts.
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