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Literature DB >> 31179437

Vitamin C in Cancer Therapeutics and Metastasis.

Abstract

There have been significant increased publications of preclinical studies and clinical trials of vitamin C (ascorbate) on cancer therapeutics in the past a few years. In this communication reflecting my personal opinions, I will highlight the main points of current research status; discuss impacts of vitamin C on immune cell function and inflammation at tumor microenvironment, and tumor metastasis; and propose stimulating questions and direction for future research in this area.

Entities: CellLine Chemical Disease Gene Species

Year: 2019 PMID： 31179437 PMCID： PMC6553485 DOI： 10.29011/2575-8241.001127

Source DB: PubMed Journal: J Orthop Res Ther ISSN： 2575-8241

21 in total

1. Ascorbic-acid Treatment for Progressive Bone Metastases After Radiotherapy: A Pilot Study.

Authors: Huriye Senay Kiziltan; Ayse Gunes Bayir; Murat Demirtas; Ismail Meral; Ozgur Taspinar; Ali Hikmet Eris; Teoman Aydin; Alparslan Mayadagli
Journal: Altern Ther Health Med Date: 2014-10 Impact factor: 1.305

Review 2. Matrix metalloproteinases and tumor metastasis.

Authors: Elena I Deryugina; James P Quigley
Journal: Cancer Metastasis Rev Date: 2006-03 Impact factor: 9.264

3. Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization.

Authors: J Orbe; J A Rodríguez; R Arias; M Belzunce; B Nespereira; M Pérez-Ilzarbe; C Roncal; J A Páramo
Journal: Atherosclerosis Date: 2003-03 Impact factor: 5.162

4. Vitamin C treatment reduces elevated C-reactive protein.

Authors: Gladys Block; Christopher D Jensen; Tapashi B Dalvi; Edward P Norkus; Mark Hudes; Patricia B Crawford; Nina Holland; Ellen B Fung; Laurie Schumacher; Paul Harmatz
Journal: Free Radic Biol Med Date: 2008-10-10 Impact factor: 7.376

5. Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan.

Authors: Odilia N Okorukwu; Koen P Vercruysse
Journal: J Enzyme Inhib Med Chem Date: 2003-08 Impact factor: 5.051

Review 6. Emerging roles for hyaluronidase in cancer metastasis and therapy.

Authors: Caitlin O McAtee; Joseph J Barycki; Melanie A Simpson
Journal: Adv Cancer Res Date: 2014 Impact factor: 6.242

7. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

Authors: E Cameron; L Pauling
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

Vitamin C in Cancer Therapeutics and Metastasis.

1. Ascorbic-acid Treatment for Progressive Bone Metastases After Radiotherapy: A Pilot Study.

Review 2. Matrix metalloproteinases and tumor metastasis.

3. Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization.

4. Vitamin C treatment reduces elevated C-reactive protein.

5. Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan.

Review 6. Emerging roles for hyaluronidase in cancer metastasis and therapy.

7. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

8. Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies.

Review 9. Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies.

10. Vitamin C: a novel regulator of neutrophil extracellular trap formation.

Review 1. Role of vitamin C in preventing of COVID-19 infection, progression and severity.

Review 2. Immunomodulatory and Antimicrobial Effects of Vitamin C.