Literature DB >> 31176778

Multidrug resistance-associated protein 4 in pharmacology: Overview of its contribution to pharmacokinetics, pharmacodynamics and pharmacogenetics.

Joseph Berthier1, Hélène Arnion2, Franck Saint-Marcoux1, Nicolas Picard3.   

Abstract

MRP4 is an ABC membrane transporter involved in clinical outcomes as it is located in many tissues that manages the transport and the elimination of many drugs. This review explores the implication of MRP4 in clinical pharmacology and the importance of its genetic variability. Although there is no specific recommendation regarding the study of MRP4 in drug development, it should be considered when drugs are eliminated by the kidney or liver or when drug-drug interactions are expected.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anti-infectious and anti-cancer drugs; Drug-drug interactions; Multidrug resistance-associated protein 4; Pharmacogenetics

Mesh：

Substances：

Year:  2019        PMID： 31176778     DOI： 10.1016/j.lfs.2019.06.015

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  9 in total

1.  Important roles of transporters in the pharmacokinetics of anti-viral nucleoside/nucleotide analogs.

Authors:  Mengbi Yang; Xin Xu
Journal:  Expert Opin Drug Metab Toxicol       Date:  2022-09-09       Impact factor: 4.936

2.  Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991.

Authors:  Edgardo Becerra; Laura Berumen; Valeria Soto-Ontiveros; Guadalupe García-Alcocer
Journal:  Medicina (Kaunas)       Date:  2022-05-24       Impact factor: 2.948

Review 3.  Role of Genetic Variations in the Hepatic Handling of Drugs.

Authors:  Jose J G Marin; Maria A Serrano; Maria J Monte; Anabel Sanchez-Martin; Alvaro G Temprano; Oscar Briz; Marta R Romero
Journal:  Int J Mol Sci       Date:  2020-04-20       Impact factor: 5.923

4.  Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics.

Authors:  Edgardo Becerra; Giovanny Aguilera-Durán; Laura Berumen; Antonio Romo-Mancillas; Guadalupe García-Alcocer
Journal:  Molecules       Date:  2021-02-17       Impact factor: 4.411

5.  Contribution of Uptake and Efflux Transporters to Oral Pharmacokinetics of Furosemide.

Authors:  Revathi Chapa; Cindy Yanfei Li; Abdul Basit; Aarzoo Thakur; Mayur K Ladumor; Sheena Sharma; Saranjit Singh; Arzu Selen; Bhagwat Prasad
Journal:  ACS Omega       Date:  2020-12-15

Review 6.  Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer.

Authors:  Wenxiao Jiang; Guiqing Cai; Peter Hu; Yue Wang
Journal:  Acta Pharm Sin B       Date:  2021-02-10       Impact factor: 11.413

7.  Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

Authors:  Marianne Rodrigues Fernandes; Juliana Carla Gomes Rodrigues; Elizabeth Ayres Fragoso Dobbin; Lucas Favacho Pastana; Danielle Feio da Costa; Williams Fernandes Barra; Antônio André Conde Modesto; Paula Baraúna de Assumpção; Artur Luiz da Costa Silva; Sidney Emanuel Batista Dos Santos; Rommel Mario Rodriguez Burbano; Paulo Pimentel de Assumpção; Ney Pereira Carneiro Dos Santos
Journal:  Cancer Chemother Pharmacol       Date:  2021-07-31       Impact factor: 3.333

8.  Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retinas.

Authors:  Kyung Woo Kim; Sentaro Kusuhara; Atsuko Katsuyama-Yoshikawa; Sho Nobuyoshi; Megumi Kitamura; Sotaro Mori; Noriyuki Sotani; Kaori Ueda; Wataru Matsumiya; Akiko Miki; Takuji Kurimoto; Hisanori Imai; Makoto Nakamura
Journal:  Antioxidants (Basel)       Date:  2021-03-15

9.  GWAS Hits for Bilateral Convergent Strabismus with Exophthalmos in Holstein Cattle Using Imputed Sequence Level Genotypes.

Authors:  Anke Bögeholz; Clemens Falker-Gieske; Monika Guélat; Corinne Gurtner; Sibylle Hunziker; Anna Oevermann; Georg Thaller; Cord Drögemüller; Jens Tetens
Journal:  Genes (Basel)       Date:  2021-07-04       Impact factor: 4.096
  9 in total

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