| Literature DB >> 3117047 |
R McNerney1, D Darling, A Johnstone.
Abstract
In lymphocytes stimulated with the mitogen phytohaemagglutinin, an inhibitor of the enzyme ADP-ribosyltransferase (ADPRT) completely blocks the proliferative response and the increase in expression of the proto-oncogene c-myc without affecting c-fos significantly. Conversely, in fibroblasts the serum-induced growth is not affected by the ADPRT inhibitor, and both oncogenes are dramatically super-induced. Hence there are differences between lymphocyte and fibroblast early responses to mitogenic stimulation and also between regulation of c-fos and c-myc gene expression.Entities:
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Year: 1987 PMID： 3117047 PMCID： PMC1148164 DOI： 10.1042/bj2450605
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857