Jill Pell1, Naveed Sattar2, Jason M R Gill2, Stuart R Gray3, Carlos A Celis-Morales2,4, Donald M Lyall1, Fanny Petermann2,1, Jana Anderson1, Joey Ward1, Stamatina Iliodromiti2, Daniel F Mackay1, Paul Welsh2, Mark E S Bailey5. 1. Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK. 2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK. 3. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK. stuart.gray@glasgow.ac.uk. 4. Centro de Investigación en Fisiología del Ejercicio (CIFE), Universidad Mayor, Santiago, Chile. 5. School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Abstract
OBJECTIVE: To investigate whether the association between a genetic profile risk score for obesity (GPRS-obesity) (based on 93 SNPs) and body mass index (BMI) was modified by physical activity (PA), cardiorespiratory fitness, commuting mode, walking pace and sedentary behaviours. METHODS: For the analyses we used cross-sectional baseline data from 310,652 participants in the UK Biobank study. We investigated interaction effects of GPRS-obesity with objectively measured and self-reported PA, cardiorespiratory fitness, commuting mode, walking pace, TV viewing, playing computer games, PC-screen time and total sedentary behaviour on BMI. Body mass index (BMI) was the main outcome measure. RESULTS: GPRS-obesity was associated with BMI (β:0.54 kg.m-2 per standard deviation (SD) increase in GPRS, [95% CI: 0.53; 0.56]; P = 2.1 × 10-241). There was a significant interaction between GPRS-obesity and objectively measured PA (P[interaction] = 3.3 × 10-11): among inactive individuals, BMI was higher by 0.58 kg.m-2 per SD increase in GPRS-obesity (p = 1.3 × 10-70) whereas among active individuals the relevant BMI difference was less (β:0.33 kg.m-2, p = 6.4 × 10-41). We observed similar patterns for fitness (Unfit β:0.72 versus Fit β:0.36 kg.m-2, P[interaction] = 1.4 × 10-11), walking pace (Slow β:0.91 versus Brisk β:0.38 kg.m-2, P[interaction] = 8.1 × 10-27), discretionary sedentary behaviour (High β:0.64 versus Low β:0.48 kg.m-2, P[interaction] = 9.1 × 10-12), TV viewing (High β:0.62 versus Low β:0.47 kg.m-2, P[interaction] = 1.7 × 10-11), PC-screen time (High β:0.82 versus Low β:0.54 kg.m-2, P[interaction] = 0.0004) and playing computer games (Often β:0.69 versus Low β:0.52 kg.m-2, P[interaction] = 8.9 × 10-10). No significant interactions were found for commuting mode (car, public transport, active commuters). CONCLUSIONS: Physical activity, sedentary behaviours and fitness modify the extent to which a set of the most important known adiposity variants affect BMI. This suggests that the adiposity benefits of high PA and low sedentary behaviour may be particularly important in individuals with high genetic risk for obesity.
OBJECTIVE: To investigate whether the association between a genetic profile risk score for obesity (GPRS-obesity) (based on 93 SNPs) and body mass index (BMI) was modified by physical activity (PA), cardiorespiratory fitness, commuting mode, walking pace and sedentary behaviours. METHODS: For the analyses we used cross-sectional baseline data from 310,652 participants in the UK Biobank study. We investigated interaction effects of GPRS-obesity with objectively measured and self-reported PA, cardiorespiratory fitness, commuting mode, walking pace, TV viewing, playing computer games, PC-screen time and total sedentary behaviour on BMI. Body mass index (BMI) was the main outcome measure. RESULTS: GPRS-obesity was associated with BMI (β:0.54 kg.m-2 per standard deviation (SD) increase in GPRS, [95% CI: 0.53; 0.56]; P = 2.1 × 10-241). There was a significant interaction between GPRS-obesity and objectively measured PA (P[interaction] = 3.3 × 10-11): among inactive individuals, BMI was higher by 0.58 kg.m-2 per SD increase in GPRS-obesity (p = 1.3 × 10-70) whereas among active individuals the relevant BMI difference was less (β:0.33 kg.m-2, p = 6.4 × 10-41). We observed similar patterns for fitness (Unfit β:0.72 versus Fit β:0.36 kg.m-2, P[interaction] = 1.4 × 10-11), walking pace (Slow β:0.91 versus Brisk β:0.38 kg.m-2, P[interaction] = 8.1 × 10-27), discretionary sedentary behaviour (High β:0.64 versus Low β:0.48 kg.m-2, P[interaction] = 9.1 × 10-12), TV viewing (High β:0.62 versus Low β:0.47 kg.m-2, P[interaction] = 1.7 × 10-11), PC-screen time (High β:0.82 versus Low β:0.54 kg.m-2, P[interaction] = 0.0004) and playing computer games (Often β:0.69 versus Low β:0.52 kg.m-2, P[interaction] = 8.9 × 10-10). No significant interactions were found for commuting mode (car, public transport, active commuters). CONCLUSIONS: Physical activity, sedentary behaviours and fitness modify the extent to which a set of the most important known adiposity variants affect BMI. This suggests that the adiposity benefits of high PA and low sedentary behaviour may be particularly important in individuals with high genetic risk for obesity.
Authors: C Bouchard; A Tremblay; J P Després; A Nadeau; P J Lupien; G Thériault; J Dussault; S Moorjani; S Pinault; G Fournier Journal: N Engl J Med Date: 1990-05-24 Impact factor: 91.245
Authors: Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher Journal: Nature Date: 2009-10-08 Impact factor: 49.962
Authors: Evan E Eichler; Jonathan Flint; Greg Gibson; Augustine Kong; Suzanne M Leal; Jason H Moore; Joseph H Nadeau Journal: Nat Rev Genet Date: 2010-06 Impact factor: 53.242
Authors: Adam E Locke; Bratati Kahali; Sonja I Berndt; Anne E Justice; Tune H Pers; Felix R Day; Corey Powell; Sailaja Vedantam; Martin L Buchkovich; Jian Yang; Damien C Croteau-Chonka; Tonu Esko; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Zoltán Kutalik; Jian'an Luan; Reedik Mägi; Joshua C Randall; Thomas W Winkler; Andrew R Wood; Tsegaselassie Workalemahu; Jessica D Faul; Jennifer A Smith; Jing Hua Zhao; Wei Zhao; Jin Chen; Rudolf Fehrmann; Åsa K Hedman; Juha Karjalainen; Ellen M Schmidt; Devin Absher; Najaf Amin; Denise Anderson; Marian Beekman; Jennifer L Bolton; Jennifer L Bragg-Gresham; Steven Buyske; Ayse Demirkan; Guohong Deng; Georg B Ehret; Bjarke Feenstra; Mary F Feitosa; Krista Fischer; Anuj Goel; Jian Gong; Anne U Jackson; Stavroula Kanoni; Marcus E Kleber; Kati Kristiansson; Unhee Lim; Vaneet Lotay; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Sarah E Medland; Michael A Nalls; Cameron D Palmer; Dorota Pasko; Sonali Pechlivanis; Marjolein J Peters; Inga Prokopenko; Dmitry Shungin; Alena Stančáková; Rona J Strawbridge; Yun Ju Sung; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sander W van der Laan; Jessica van Setten; Jana V Van Vliet-Ostaptchouk; Zhaoming Wang; Loïc Yengo; Weihua Zhang; Aaron Isaacs; Eva Albrecht; Johan Ärnlöv; Gillian M Arscott; Antony P Attwood; Stefania Bandinelli; Amy Barrett; Isabelita N Bas; Claire Bellis; Amanda J Bennett; Christian Berne; Roza Blagieva; Matthias Blüher; Stefan Böhringer; Lori L Bonnycastle; Yvonne Böttcher; Heather A Boyd; Marcel Bruinenberg; Ida H Caspersen; Yii-Der Ida Chen; Robert Clarke; E Warwick Daw; Anton J M de Craen; Graciela Delgado; Maria Dimitriou; Alex S F Doney; Niina Eklund; Karol Estrada; Elodie Eury; Lasse Folkersen; Ross M Fraser; Melissa E Garcia; Frank Geller; Vilmantas Giedraitis; Bruna Gigante; Alan S Go; Alain Golay; Alison H Goodall; Scott D Gordon; Mathias Gorski; Hans-Jörgen Grabe; Harald Grallert; Tanja B Grammer; Jürgen Gräßler; Henrik Grönberg; Christopher J Groves; Gaëlle Gusto; Jeffrey Haessler; Per Hall; Toomas Haller; Goran Hallmans; Catharina A Hartman; Maija Hassinen; Caroline Hayward; Nancy L Heard-Costa; Quinta Helmer; Christian Hengstenberg; Oddgeir Holmen; Jouke-Jan Hottenga; Alan L James; Janina M Jeff; Åsa Johansson; Jennifer Jolley; Thorhildur Juliusdottir; Leena Kinnunen; Wolfgang Koenig; Markku Koskenvuo; Wolfgang Kratzer; Jaana Laitinen; Claudia Lamina; Karin Leander; Nanette R Lee; Peter Lichtner; Lars Lind; Jaana Lindström; Ken Sin Lo; Stéphane Lobbens; Roberto Lorbeer; Yingchang Lu; François Mach; Patrik K E Magnusson; Anubha Mahajan; Wendy L McArdle; Stela McLachlan; Cristina Menni; Sigrun Merger; Evelin Mihailov; Lili Milani; Alireza Moayyeri; Keri L Monda; Mario A Morken; Antonella Mulas; Gabriele Müller; Martina Müller-Nurasyid; Arthur W Musk; Ramaiah Nagaraja; Markus M Nöthen; Ilja M Nolte; Stefan Pilz; Nigel W Rayner; Frida Renstrom; Rainer Rettig; Janina S Ried; Stephan Ripke; Neil R Robertson; Lynda M Rose; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Fredrick R Schumacher; William R Scott; Thomas Seufferlein; Jianxin Shi; Albert Vernon Smith; Joanna Smolonska; Alice V Stanton; Valgerdur Steinthorsdottir; Kathleen Stirrups; Heather M Stringham; Johan Sundström; Morris A Swertz; Amy J Swift; Ann-Christine Syvänen; Sian-Tsung Tan; Bamidele O Tayo; Barbara Thorand; Gudmar Thorleifsson; Jonathan P Tyrer; Hae-Won Uh; Liesbeth Vandenput; Frank C Verhulst; Sita H Vermeulen; Niek Verweij; Judith M Vonk; Lindsay L Waite; Helen R Warren; Dawn Waterworth; Michael N Weedon; Lynne R Wilkens; Christina Willenborg; Tom Wilsgaard; Mary K Wojczynski; Andrew Wong; Alan F Wright; Qunyuan Zhang; Eoin P Brennan; Murim Choi; Zari Dastani; Alexander W Drong; Per Eriksson; Anders Franco-Cereceda; Jesper R Gådin; Ali G Gharavi; Michael E Goddard; Robert E Handsaker; Jinyan Huang; Fredrik Karpe; Sekar Kathiresan; Sarah Keildson; Krzysztof Kiryluk; Michiaki Kubo; Jong-Young Lee; Liming Liang; Richard P Lifton; Baoshan Ma; Steven A McCarroll; Amy J McKnight; Josine L Min; Miriam F Moffatt; Grant W Montgomery; Joanne M Murabito; George Nicholson; Dale R Nyholt; Yukinori Okada; John R B Perry; Rajkumar Dorajoo; Eva Reinmaa; Rany M Salem; Niina Sandholm; Robert A Scott; Lisette Stolk; Atsushi Takahashi; Toshihiro Tanaka; Ferdinand M van 't Hooft; Anna A E Vinkhuyzen; Harm-Jan Westra; Wei Zheng; Krina T Zondervan; Andrew C Heath; Dominique Arveiler; Stephan J L Bakker; John Beilby; Richard N Bergman; John Blangero; Pascal Bovet; Harry Campbell; Mark J Caulfield; Giancarlo Cesana; Aravinda Chakravarti; Daniel I Chasman; Peter S Chines; Francis S Collins; Dana C Crawford; L Adrienne Cupples; Daniele Cusi; John Danesh; Ulf de Faire; Hester M den Ruijter; Anna F Dominiczak; Raimund Erbel; Jeanette Erdmann; Johan G Eriksson; Martin Farrall; Stephan B Felix; Ele Ferrannini; Jean Ferrières; Ian Ford; Nita G Forouhi; Terrence Forrester; Oscar H Franco; Ron T Gansevoort; Pablo V Gejman; Christian Gieger; Omri Gottesman; Vilmundur Gudnason; Ulf Gyllensten; Alistair S Hall; Tamara B Harris; Andrew T Hattersley; Andrew A Hicks; Lucia A Hindorff; Aroon D Hingorani; Albert Hofman; Georg Homuth; G Kees Hovingh; Steve E Humphries; Steven C Hunt; Elina Hyppönen; Thomas Illig; Kevin B Jacobs; Marjo-Riitta Jarvelin; Karl-Heinz Jöckel; Berit Johansen; Pekka Jousilahti; J Wouter Jukema; Antti M Jula; Jaakko Kaprio; John J P Kastelein; Sirkka M Keinanen-Kiukaanniemi; Lambertus A Kiemeney; Paul Knekt; Jaspal S Kooner; Charles Kooperberg; Peter Kovacs; Aldi T Kraja; Meena Kumari; Johanna Kuusisto; Timo A Lakka; Claudia Langenberg; Loic Le Marchand; Terho Lehtimäki; Valeriya Lyssenko; Satu Männistö; André Marette; Tara C Matise; Colin A McKenzie; Barbara McKnight; Frans L Moll; Andrew D Morris; Andrew P Morris; Jeffrey C Murray; Mari Nelis; Claes Ohlsson; Albertine J Oldehinkel; Ken K Ong; Pamela A F Madden; Gerard Pasterkamp; John F Peden; Annette Peters; Dirkje S Postma; Peter P Pramstaller; Jackie F Price; Lu Qi; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Paul M Ridker; John D Rioux; Marylyn D Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J Samani; Jouko Saramies; Mark A Sarzynski; Heribert Schunkert; Peter E H Schwarz; Peter Sever; Alan R Shuldiner; Juha Sinisalo; Ronald P Stolk; Konstantin Strauch; Anke Tönjes; David-Alexandre Trégouët; Angelo Tremblay; Elena Tremoli; Jarmo Virtamo; Marie-Claude Vohl; Uwe Völker; Gérard Waeber; Gonneke Willemsen; Jacqueline C Witteman; M Carola Zillikens; Linda S Adair; Philippe Amouyel; Folkert W Asselbergs; Themistocles L Assimes; Murielle Bochud; Bernhard O Boehm; Eric Boerwinkle; Stefan R Bornstein; Erwin P Bottinger; Claude Bouchard; Stéphane Cauchi; John C Chambers; Stephen J Chanock; Richard S Cooper; Paul I W de Bakker; George Dedoussis; Luigi Ferrucci; Paul W Franks; Philippe Froguel; Leif C Groop; Christopher A Haiman; Anders Hamsten; Jennie Hui; David J Hunter; Kristian Hveem; Robert C Kaplan; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Nicholas G Martin; Winfried März; Mads Melbye; Andres Metspalu; Susanne Moebus; Patricia B Munroe; Inger Njølstad; Ben A Oostra; Colin N A Palmer; Nancy L Pedersen; Markus Perola; Louis Pérusse; Ulrike Peters; Chris Power; Thomas Quertermous; Rainer Rauramaa; Fernando Rivadeneira; Timo E Saaristo; Danish Saleheen; Naveed Sattar; Eric E Schadt; David Schlessinger; P Eline Slagboom; Harold Snieder; Tim D Spector; Unnur Thorsteinsdottir; Michael Stumvoll; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; Pim van der Harst; Mark Walker; Henri Wallaschofski; Nicholas J Wareham; Hugh Watkins; David R Weir; H-Erich Wichmann; James F Wilson; Pieter Zanen; Ingrid B Borecki; Panos Deloukas; Caroline S Fox; Iris M Heid; Jeffrey R O'Connell; David P Strachan; Kari Stefansson; Cornelia M van Duijn; Gonçalo R Abecasis; Lude Franke; Timothy M Frayling; Mark I McCarthy; Peter M Visscher; André Scherag; Cristen J Willer; Michael Boehnke; Karen L Mohlke; Cecilia M Lindgren; Jacques S Beckmann; Inês Barroso; Kari E North; Erik Ingelsson; Joel N Hirschhorn; Ruth J F Loos; Elizabeth K Speliotes Journal: Nature Date: 2015-02-12 Impact factor: 49.962
Authors: Timothy S Church; Diana M Thomas; Catrine Tudor-Locke; Peter T Katzmarzyk; Conrad P Earnest; Ruben Q Rodarte; Corby K Martin; Steven N Blair; Claude Bouchard Journal: PLoS One Date: 2011-05-25 Impact factor: 3.240