Literature DB >> 31165682

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters.

Donald M Bers1, Yang K Xiang1, Manuela Zaccolo2.   

Abstract

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.

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Year:  2019        PMID： 31165682      PMCID： PMC6863374          DOI： 10.1152/physiol.00002.2019

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  75 in total

1.  β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.

Authors:  Jorge A Negroni; Stefano Morotti; Elena C Lascano; Aldrin V Gomes; Eleonora Grandi; José L Puglisi; Donald M Bers
Journal:  J Mol Cell Cardiol       Date:  2015-02-25       Impact factor: 5.000

2.  Arrhythmogenic transient dynamics in cardiac myocytes.

Authors:  Yuanfang Xie; Leighton T Izu; Donald M Bers; Daisuke Sato
Journal:  Biophys J       Date:  2014-03-18       Impact factor: 4.033

3.  Protein kinase A type I and type II define distinct intracellular signaling compartments.

Authors:  Giulietta Di Benedetto; Anna Zoccarato; Valentina Lissandron; Anna Terrin; Xiang Li; Miles D Houslay; George S Baillie; Manuela Zaccolo
Journal:  Circ Res       Date:  2008-08-28       Impact factor: 17.367

Review 4.  Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown.

Authors:  Miles D Houslay
Journal:  Trends Biochem Sci       Date:  2009-10-26       Impact factor: 13.807

Review 5.  Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes.

Authors:  Jabe M Best; Timothy J Kamp
Journal:  J Mol Cell Cardiol       Date:  2011-08-23       Impact factor: 5.000

6.  How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?

Authors:  Yuanfang Xie; Eleonora Grandi; Donald M Bers; Daisuke Sato
Journal:  Europace       Date:  2014-03       Impact factor: 5.214

7.  cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.

Authors:  J Jurevicius; R Fischmeister
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

8.  A genetically encoded, fluorescent indicator for cyclic AMP in living cells.

Authors:  M Zaccolo; F De Giorgi; C Y Cho; L Feng; T Knapp; P A Negulescu; S S Taylor; R Y Tsien; T Pozzan
Journal:  Nat Cell Biol       Date:  2000-01       Impact factor: 28.824

9.  Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.

Authors:  Manuela Zaccolo; Tullio Pozzan
Journal:  Science       Date:  2002-03-01       Impact factor: 47.728

10.  Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.

Authors:  Vedangi Sample; Lisa M DiPilato; Jason H Yang; Qiang Ni; Jeffrey J Saucerman; Jin Zhang
Journal:  Nat Chem Biol       Date:  2012-02-26       Impact factor: 15.040
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  14 in total

1.  AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels.

Authors:  Pulak Kar; Pradeep Barak; Anna Zerio; Yu-Ping Lin; Amy J Parekh; Val J Watts; Dermot M F Cooper; Manuela Zaccolo; Holger Kramer; Anant B Parekh
Journal:  Function (Oxf)       Date:  2021-07-29

2.  Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility.

Authors:  Ying Wang; Qian Shi; Minghui Li; Meimi Zhao; Raghavender Reddy Gopireddy; Jian-Peng Teoh; Bing Xu; Chaoqun Zhu; Kyle E Ireton; Sanghavi Srinivasan; Shaoliang Chen; Paul J Gasser; Julie Bossuyt; Johannes W Hell; Donald M Bers; Yang K Xiang
Journal:  Circ Res       Date:  2020-11-13       Impact factor: 17.367

Review 3.  Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.

Authors:  Katrina F Ostrom; Justin E LaVigne; Tarsis F Brust; Roland Seifert; Carmen W Dessauer; Val J Watts; Rennolds S Ostrom
Journal:  Physiol Rev       Date:  2021-10-26       Impact factor: 37.312

4.  Phosphoproteomic identification of vasopressin-regulated protein kinases in collecting duct cells.

Authors:  Arnab Datta; Chin-Rang Yang; Karim Salhadar; Euijung Park; Chung-Lin Chou; Viswanathan Raghuram; Mark A Knepper
Journal:  Br J Pharmacol       Date:  2021-02-14       Impact factor: 9.473

Review 5.  The Role of the Popeye Domain Containing Gene Family in Organ Homeostasis.

Authors:  Johanna Ndamwena Amunjela; Alexander H Swan; Thomas Brand
Journal:  Cells       Date:  2019-12-07       Impact factor: 6.600

Review 6.  Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis.

Authors:  Vladimir Dikolayev; Turlybek Tuganbekov; Viacheslav O Nikolaev
Journal:  Front Physiol       Date:  2019-11-26       Impact factor: 4.566

Review 7.  Imaging cAMP nanodomains in the heart.

Authors:  Ying-Chi Chao; Nicoletta C Surdo; Sergio Pantano; Manuela Zaccolo
Journal:  Biochem Soc Trans       Date:  2019-10-31       Impact factor: 5.407

8.  Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy.

Authors:  Marcella Brescia; Ying-Chi Chao; Andreas Koschinski; Jakub Tomek; Manuela Zaccolo
Journal:  Int J Mol Sci       Date:  2020-09-25       Impact factor: 5.923

9.  Cardiac Hypertrophy Changes Compartmentation of cAMP in Non-Raft Membrane Microdomains.

Authors:  Nikoleta Pavlaki; Kirstie A De Jong; Birgit Geertz; Viacheslav O Nikolaev; Alexander Froese
Journal:  Cells       Date:  2021-03-03       Impact factor: 6.600

10.  PKA compartmentalization links cAMP signaling and autophagy.

Authors:  Francesca Grisan; Liliana F Iannucci; Nicoletta C Surdo; Andrea Gerbino; Sofia Zanin; Giulietta Di Benedetto; Tullio Pozzan; Konstantinos Lefkimmiatis
Journal:  Cell Death Differ       Date:  2021-03-19       Impact factor: 15.828
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