Literature DB >> 3116255

Synthesis and antineoplastic activity of 1a-formyl and 1a-thioformyl derivatives of mitomycin C and 2-methylaziridine.

P L Fishbein1, H Kohn.   

Abstract

A select number of 1-formyl- and 1-thioformyl-2-methylaziridine derivatives and the corresponding 1a-substituted mitomycin C analogues were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Select compounds were also tested in vivo with murine melanoma B16. Several of the mitomycin C derivatives displayed activity and some of the mitomycin C analogues were comparable in activity to the parent compound.

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Year:  1987        PMID： 3116255     DOI： 10.1021/jm00393a015

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

Authors:  Rong Huang; Marc A Holbert; Mary Katherine Tarrant; Sandrine Curtet; David R Colquhoun; Beverley M Dancy; Blair C Dancy; Yousang Hwang; Yong Tang; Katrina Meeth; Ronen Marmorstein; Robert N Cole; Saadi Khochbin; Philip A Cole
Journal:  J Am Chem Soc       Date:  2010-07-28       Impact factor: 15.419

2.  Combining asymmetric catalysis with natural product functionalization through enantioselective alpha-fluorination.

Authors:  Jeremy Erb; Ethan Alden-Danforth; Nathan Kopf; Michael T Scerba; Thomas Lectka
Journal:  J Org Chem       Date:  2010-02-05       Impact factor: 4.354

3.  Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea.

Authors:  Aleksandra Kowalczyk; Adam M Pieczonka; Michał Rachwalski; Stanisław Leśniak; Paweł Stączek
Journal:  Molecules       Date:  2017-12-25       Impact factor: 4.411
  3 in total

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