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Literature DB >> 31160282

Multiple Copies of qnrA1 on an IncA/C₂ Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant.

Laura Vinué¹, Mohamad R A Sater², Ian Herriott², Miriam H Huntley², George A Jacoby³, David C Hooper⁴.

Abstract

In a previous study, mutants with enhanced ciprofloxacin resistance (Cipr) were selected from Escherichia coli J53/pMG252 carrying qnrA1 Strain J53 Cipr 8-2 showed an increase in the copy number and transcription level of qnrA1 We sequenced the plasmids on Illumina and MinION platforms. Parental plasmid pMG252 and plasmid pMG252A from strain J53 Cipr 8-2 were almost identical, except for the region containing qnrA1 that in pMG252A contained 4 additional copies of the qnrA1-qacEΔ1-sul1-ISCR1 region.

Entities: Chemical Gene Mutation Species

Keywords: A/C2 plasmid; Escherichia colizzm321990; ISCR1zzm321990; ciprofloxacin; qnrA1zzm321990

Mesh：

Substances：

Year: 2019 PMID： 31160282 PMCID： PMC6658789 DOI： 10.1128/AAC.00718-19

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate.

Authors: A M Queenan; S Jenkins; K Bush
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

2. Cold shock induces qnrA expression in Shewanella algae.

Authors: Hong Bin Kim; Chi Hye Park; Mariah Gavin; George A Jacoby; David C Hooper
Journal: Antimicrob Agents Chemother Date: 2010-11-15 Impact factor: 5.191

Review 3. The A to Z of A/C plasmids.

Authors: Christopher J Harmer; Ruth M Hall
Journal: Plasmid Date: 2015-04-21 Impact factor: 3.466

Review 4. Plasmid-mediated quinolone resistance.

Authors: George A Jacoby; Jacob Strahilevitz; David C Hooper
Journal: Microbiol Spectr Date: 2014-10

5. Coexistence of plasmid-mediated quinolone resistance determinants and AmpC-Beta-Lactamases in Escherichia coli strains in Egypt.

Authors: N K Abd El-Aziz; A A Gharib
Journal: Cell Mol Biol (Noisy-le-grand) Date: 2015-10-16 Impact factor: 1.770

6. Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.

Authors: Laura Vinué; Marian A Corcoran; David C Hooper; George A Jacoby
Journal: Antimicrob Agents Chemother Date: 2015-12-28 Impact factor: 5.191

7. Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid.

Authors: Ulises Garza-Ramos; Humberto Barrios; Maria Jose Hernandez-Vargas; Teresa Rojas-Moreno; Fernando Reyna-Flores; Perla Tinoco; Victor Othon; Laurent Poirel; Patrice Nordmann; Vincent Cattoir; Guillermo Ruiz-Palacios; Jose Luis Fernandez; Rosa Isela Santamaria; Patricia Bustos; Natividad Castro; Jesus Silva-Sanchez
Journal: J Antimicrob Chemother Date: 2012-04-18 Impact factor: 5.790

Multiple Copies of qnrA1 on an IncA/C₂ Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant.

1. Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate.

2. Cold shock induces qnrA expression in Shewanella algae.

Review 3. The A to Z of A/C plasmids.

Review 4. Plasmid-mediated quinolone resistance.

5. Coexistence of plasmid-mediated quinolone resistance determinants and AmpC-Beta-Lactamases in Escherichia coli strains in Egypt.

6. Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.

7. Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid.

Review 8. Plasmid-mediated quinolone resistance: a multifaceted threat.

9. Plasmid-mediated quinolone resistance determinants in Enterobacteriaceae from urine clinical samples.

10. BIGSdb: Scalable analysis of bacterial genome variation at the population level.

Review 1. Transferable Mechanisms of Quinolone Resistance from 1998 Onward.