Ece Meram1, Colin Harari2, Gabe Shaughnessy3, Martin Wagner3, Chris L Brace4, Charles A Mistretta4, Michael A Speidel3, Paul F Laeseke5. 1. Section of Interventional Radiology, Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, D4-352, Madison, WI 53792. Electronic address: ecemeram@gmail.com. 2. School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, D4-352, Madison, WI 53792. 3. Department of Medical Physics, University of Wisconsin-Madison, 600 Highland Avenue, D4-352, Madison, WI 53792. 4. Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, D4-352, Madison, WI 53792. 5. Section of Interventional Radiology, Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, D4-352, Madison, WI 53792.
Abstract
PURPOSE: To determine the feasibility of using time-resolved 3D-digital subtraction angiography (4D-DSA) for quantifying changes in hepatic arterial blood flow and velocity during transarterial embolization. MATERIALS AND METHODS: Hepatic arteriography and selective transarterial embolization were performed in 4 female domestic swine (mean weight, 54 kg) using 100-300-μm microspheres. Conventional 2D and 4D-DSA were performed before, during, and after each embolization. From the 4D-DSA reconstructions, blood flow and velocity values were calculated for hepatic arterial branches using a pulsatility-based algorithm. 4D-DSA velocity values were compared to those measured using an intravascular Doppler wire with a linear regression analysis. Paired t-tests were used to compare data before and after embolization. RESULTS: There was a weak-to-moderate but statistically significant correlation of flow velocities measured with 4D-DSA and the Doppler wire (r = 0.35, n = 39, P = .012). For vessels with high pulsatility, the correlation was higher (r = 0.64, n = 11, P = .034), and the relationship between 4D-DSA and the Doppler wire fit a linear model with a positive bias toward the Doppler wire (failed to reject at 95% confidence level, P = .208). 4D-DSA performed after partial embolization showed a reduction in velocity in the embolized hepatic arteries compared to pre-embolization (mean, 3.96 ± 0.74 vs 11.8 2± 2.15 cm/s, P = .006). CONCLUSION: Quantitative 4D-DSA can depict changes in hepatic arterial blood velocity during transarterial embolization in a swine model. Further work is needed to optimize 4D-DSA acquisitions and to investigate its applicability in humans.
PURPOSE: To determine the feasibility of using time-resolved 3D-digital subtraction angiography (4D-DSA) for quantifying changes in hepatic arterial blood flow and velocity during transarterial embolization. MATERIALS AND METHODS: Hepatic arteriography and selective transarterial embolization were performed in 4 female domestic swine (mean weight, 54 kg) using 100-300-μm microspheres. Conventional 2D and 4D-DSA were performed before, during, and after each embolization. From the 4D-DSA reconstructions, blood flow and velocity values were calculated for hepatic arterial branches using a pulsatility-based algorithm. 4D-DSA velocity values were compared to those measured using an intravascular Doppler wire with a linear regression analysis. Paired t-tests were used to compare data before and after embolization. RESULTS: There was a weak-to-moderate but statistically significant correlation of flow velocities measured with 4D-DSA and the Doppler wire (r = 0.35, n = 39, P = .012). For vessels with high pulsatility, the correlation was higher (r = 0.64, n = 11, P = .034), and the relationship between 4D-DSA and the Doppler wire fit a linear model with a positive bias toward the Doppler wire (failed to reject at 95% confidence level, P = .208). 4D-DSA performed after partial embolization showed a reduction in velocity in the embolized hepatic arteries compared to pre-embolization (mean, 3.96 ± 0.74 vs 11.8 2± 2.15 cm/s, P = .006). CONCLUSION: Quantitative 4D-DSA can depict changes in hepatic arterial blood velocity during transarterial embolization in a swine model. Further work is needed to optimize 4D-DSA acquisitions and to investigate its applicability in humans.
Authors: Ece Meram; Gabe Shaughnessy; Colin Longhurst; Carson Hoffman; Martin Wagner; Charles A Mistretta; Michael A Speidel; Paul F Laeseke Journal: Eur Radiol Exp Date: 2020-07-02
Authors: Carson Hoffman; Sarvesh Periyasamy; Colin Longhurst; Rafael Medero; Alejandro Roldan-Alzate; Michael A Speidel; Paul F Laeseke Journal: CVIR Endovasc Date: 2021-01-07